CAJ | 학술논문

目的：分析原发性乳腺淋巴瘤(primary breast lymphoma,PBL)的临床特点及预后,以提高对本病的认识。方法收集并回顾性分析中山市博爱医院2001年1月~2012年12月收治的原发性乳腺淋巴瘤临床资料和治疗情况。结果病理均是B细胞性来源(25/25),弥漫大B细胞型占61.5%(16/25)。本组患者总的5年生存率分别为44%,含有手术治疗模式较无手术治疗模式的5年生存时间、5年局部控制率、5年无远处转移率无显著差异(P>0.05)；含有放疗模式治疗较无放疗治疗模式的5年生存时间、5年无远处转移率无显著差异(P>0.05),但是5年局部控制率比较,差异有统计学意义(P<0.05)；含有化疗治疗模式较无化疗治疗模式的5年生存时间、5年局部控制率无显著差异(P>0.05),但5年无远处转移率比较,差异有统计学意义(P<0.05)。结论肿瘤分期及病理类型与PBL预后相关,局部放疗有助于提高局部控制率,化疗有助于提高远处转移控制率,手术联合放、化疗是较合理的治疗方案。
목적：분석원발성유선림파류(primary breast lymphoma,PBL)적림상특점급예후,이제고대본병적인식。방법수집병회고성분석중산시박애의원2001년1월~2012년12월수치적원발성유선림파류림상자료화치료정황。결과병리균시B세포성래원(25/25),미만대B세포형점61.5%(16/25)。본조환자총적5년생존솔분별위44%,함유수술치료모식교무수술치료모식적5년생존시간、5년국부공제솔、5년무원처전이솔무현저차이(P>0.05)；함유방료모식치료교무방료치료모식적5년생존시간、5년무원처전이솔무현저차이(P>0.05),단시5년국부공제솔비교,차이유통계학의의(P<0.05)；함유화료치료모식교무화료치료모식적5년생존시간、5년국부공제솔무현저차이(P>0.05),단5년무원처전이솔비교,차이유통계학의의(P<0.05)。결론종류분기급병리류형여PBL예후상관,국부방료유조우제고국부공제솔,화료유조우제고원처전이공제솔,수술연합방、화료시교합리적치료방안。
Objective To improve the recognition and management of primary breast lymphoma(PBL) by discussing the clinical pathological characteristics and the prognosis of PBL. Methods The clinical and treatment records of PBL pa-tients admitted in Boai hospital of zhongshan from January 2001 to December 2012 were analyzed. Results All cases were B-cell origin(25/25),61.5%(16/25)were diffuse large B-cell lymphoma origin,The 5-year overall survival was 44%. There were no significant difference in the 5-year overall survival rates, 5-year local control rates and 5-year distant control rates in patient treatment with any surgery compared with no-Surgery(P>0.05).There were no significant difference in the 5-year overall survival rates and 5-year distant control rates in patient treatment with any RT com-pared with no-RT(P>0.05),but the 5-year local control rates was significantly different(P<0.05);There were no sig-nificant difference in the 5-year overall survival rates and 5-year local control rates in patient treatment with any chemotherapy compared with no-chemotherapy (P>0.05). but the 5-year distant control rates was significant different(P<0.05). Conclusion The prognosis of PBL is related with the clinical stage and pathological type. Radiotherapy and chemotherapy respectively promote the local control and distant control. The optimal treatment is surgery combined with chemotherapy and/or radiotherapy.