CAJ | 학술논문

目的：探讨医院呼吸机相关性肺炎(VAP)病原菌分布及耐药情况,以便更好地指导临床用药。方法回顾性分析我院收治的598例机械通气患者的临床资料,从中筛选VAP患者并对其下呼吸道分泌物病原菌进行培养并鉴定结果。结果221例VAP患者下呼吸道痰液共分离出251株病原菌,其中革兰阴性菌与阳性菌分离率分别占71.3%与17.9%；革兰阴性菌与阳性菌分别以鲍曼不动杆菌与金黄色葡萄球菌分离率最高。鲍曼不动杆菌泛耐药菌株的检出率最高,达27.9%,MRSA和MRSE检出率分别为66.7%和61.5%。结论 VAP的病原菌以革兰阴性菌为主,相关菌株耐药性逐渐增高,应及时监测相关病原菌耐药性。
목적：탐토의원호흡궤상관성폐염(VAP)병원균분포급내약정황,이편경호지지도림상용약。방법회고성분석아원수치적598례궤계통기환자적림상자료,종중사선VAP환자병대기하호흡도분비물병원균진행배양병감정결과。결과221례VAP환자하호흡도담액공분리출251주병원균,기중혁란음성균여양성균분리솔분별점71.3%여17.9%；혁란음성균여양성균분별이포만불동간균여금황색포도구균분리솔최고。포만불동간균범내약균주적검출솔최고,체27.9%,MRSA화MRSE검출솔분별위66.7%화61.5%。결론 VAP적병원균이혁란음성균위주,상관균주내약성축점증고,응급시감측상관병원균내약성。
Objective To investigate the distribution and drug resistance pathogens from ventilator-associated pneumo-nia (VAP)patients for to better guide clinical treatment. Methods The medical records of 598 mechanical ventilation patients were retrospectively reviewed and the results of sputum culture and antibiotic resistance of pathogens from VAP patients were analyzed. Results The 251 strains of pathogens were isolated from lower respiratory tract sputum specimens in 221 patients with ventilator-associated pneumonia. Among them, the isolation rate of the gram-negative bacteria was the highest (71.3%),followed by the gram-positive bacteria (17.9%). The Acinetobacter baumannii and Staphylococcus were the top species in gram-negative and gram-positive bacteria, respectively. The isolation rate of the pan-resistant for Acinetobacter baumannii was 27.9% and the isolation rate of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) were 66.7% and 61.5%, respectively. Conclusion The gram-negative bacteria remain dominant in the pathogens causing VAP,and related strains are highly drug resistant. It is crucial for timely monitoring of drug resistance of the pathogens.