现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
MODERN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2014年
28期
3090-3092,3095
,共4页
痹证宁%类风湿关节炎%临床疗效%安全性
痺證寧%類風濕關節炎%臨床療效%安全性
비증저%류풍습관절염%림상료효%안전성
Bizhengning%rheumatoid Arthritis%clinical efficacy%safety
目的：观察痹证宁方治疗风寒湿型类风湿关节炎（ RA）的临床疗效及安全性，探讨中西医治疗类风湿关节炎的优势。方法采用随机对照试验，将风寒湿型类风湿关节炎患者60例随机分为观察组30例和对照组30例。对照组给予甲氨蝶呤、来氟米特治疗，观察组在此基础上加用中药痹证宁方治疗。2组均以3个月为1个疗程。观察治疗前后2组临床症状、体征、实验室指标（ ESR、RF、CRP、IL -6、MMP -3）、中医证候及关节功能的变化，比较其疗效。检查血尿常规、肝肾功能，统计2组不良反应发生情况。结果治疗3个月后，2组中医证候、临床症状、体征、ESR、CRP、RF、IL-6、MMP-3及关节功能均较治疗前有明显改善（P均﹤0.05），且治疗组改善程度均优于对照组（P均﹤0.05）。治疗组不良反应发生率明显低于对照组（P﹤0.05）。结论痹证宁方联合常规西药治疗 RA临床疗效确切，可降低 CRP、ESR、IL -6、MMP -3，并能明显改善中医证候及关节功能，且无明显不良反应，安全性高。
目的：觀察痺證寧方治療風寒濕型類風濕關節炎（ RA）的臨床療效及安全性，探討中西醫治療類風濕關節炎的優勢。方法採用隨機對照試驗，將風寒濕型類風濕關節炎患者60例隨機分為觀察組30例和對照組30例。對照組給予甲氨蝶呤、來氟米特治療，觀察組在此基礎上加用中藥痺證寧方治療。2組均以3箇月為1箇療程。觀察治療前後2組臨床癥狀、體徵、實驗室指標（ ESR、RF、CRP、IL -6、MMP -3）、中醫證候及關節功能的變化，比較其療效。檢查血尿常規、肝腎功能，統計2組不良反應髮生情況。結果治療3箇月後，2組中醫證候、臨床癥狀、體徵、ESR、CRP、RF、IL-6、MMP-3及關節功能均較治療前有明顯改善（P均﹤0.05），且治療組改善程度均優于對照組（P均﹤0.05）。治療組不良反應髮生率明顯低于對照組（P﹤0.05）。結論痺證寧方聯閤常規西藥治療 RA臨床療效確切，可降低 CRP、ESR、IL -6、MMP -3，併能明顯改善中醫證候及關節功能，且無明顯不良反應，安全性高。
목적：관찰비증저방치료풍한습형류풍습관절염（ RA）적림상료효급안전성，탐토중서의치료류풍습관절염적우세。방법채용수궤대조시험，장풍한습형류풍습관절염환자60례수궤분위관찰조30례화대조조30례。대조조급여갑안접령、래불미특치료，관찰조재차기출상가용중약비증저방치료。2조균이3개월위1개료정。관찰치료전후2조림상증상、체정、실험실지표（ ESR、RF、CRP、IL -6、MMP -3）、중의증후급관절공능적변화，비교기료효。검사혈뇨상규、간신공능，통계2조불량반응발생정황。결과치료3개월후，2조중의증후、림상증상、체정、ESR、CRP、RF、IL-6、MMP-3급관절공능균교치료전유명현개선（P균﹤0.05），차치료조개선정도균우우대조조（P균﹤0.05）。치료조불량반응발생솔명현저우대조조（P﹤0.05）。결론비증저방연합상규서약치료 RA림상료효학절，가강저 CRP、ESR、IL -6、MMP -3，병능명현개선중의증후급관절공능，차무명현불량반응，안전성고。
Objective It is to observe the clinical efficacy and safety of Bizhengning decoction combined with conventional western medicine on rheumatoid arthritis( RA)of wind-cold-wet syndrome type,and to explore the advantage of integrative medicine treatment of RA. Methods Using random-control trial 60 patients with RA of wind-cold-wet syndrome type were ran-domly divided into observation group and control group,each group had 30 cases. The control group was treated with lefluno-mide+methotrexate,and the treatment group was treated with Bizhengning decoction on the basis of control group's treatment. Both the treatment course were three months. The changes of clinical symptoms and physical signs,the levels of CRP,ESR, RF,IL-6 and MMP-3,the function of joint and TCM syndromes were observed and the curative effects were compared be-tween the two groups. The examination of blood routine,urine routine,fecal routine and liver function were taken as safety in-dexes to record the occurrences of side effects. Results After three month's treatment,the symptoms,signs,ESR and CRP, RF,IL-6,MMP-3,TCM syndrome and the function of joint were obviously improved(P﹤0. 05);and the improvements in observation group were all better than that in control group(P﹤0. 05). Conclusion Bizhengning decoction combined with con-ventional western medicine has a confirmed curative effect on RA,it can relieve the clinical symptoms and physical signs,re-duce the levels of CRP,ESR,IL-6,MMP-3,improve TCM symptoms and the function of joint,with high safety and no obvi-ous side effect.
