国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2014年
4期
243-247
,共5页
肖学敏%何艳艳%张晓峰%李诚让%王宝玺
肖學敏%何豔豔%張曉峰%李誠讓%王寶璽
초학민%하염염%장효봉%리성양%왕보새
皮肤病学%γ-分泌酶%反常性痤疮%Notch受体
皮膚病學%γ-分泌酶%反常性痤瘡%Notch受體
피부병학%γ-분비매%반상성좌창%Notch수체
Dermatology%γ-Secretase%Acne inversa%Notch receptor
γ-分泌酶是一个包含四个疏水性亚基的跨膜蛋白水解酶,可以裂解包括β淀粉样前体蛋白、Notch受体等超过30种Ⅰ型跨膜蛋白.近年来,在多个家族性和散发性反常性痤疮的病例中发现了γ-分泌酶基因存在杂合突变.越来越多的文献表明,γ-分泌酶在维持皮肤正常生理功能和诸如炎症性皮肤病、皮肤肿瘤、感染性皮肤病、性病及结缔组织病等多种皮肤疾病中发挥重要作用.尽管目前尚无临床应用,γ-分泌酶的抑制剂和激活剂可能在未来为皮肤病的预防和治疗提供新的药物.
γ-分泌酶是一箇包含四箇疏水性亞基的跨膜蛋白水解酶,可以裂解包括β澱粉樣前體蛋白、Notch受體等超過30種Ⅰ型跨膜蛋白.近年來,在多箇傢族性和散髮性反常性痤瘡的病例中髮現瞭γ-分泌酶基因存在雜閤突變.越來越多的文獻錶明,γ-分泌酶在維持皮膚正常生理功能和諸如炎癥性皮膚病、皮膚腫瘤、感染性皮膚病、性病及結締組織病等多種皮膚疾病中髮揮重要作用.儘管目前尚無臨床應用,γ-分泌酶的抑製劑和激活劑可能在未來為皮膚病的預防和治療提供新的藥物.
γ-분비매시일개포함사개소수성아기적과막단백수해매,가이렬해포괄β정분양전체단백、Notch수체등초과30충Ⅰ형과막단백.근년래,재다개가족성화산발성반상성좌창적병례중발현료γ-분비매기인존재잡합돌변.월래월다적문헌표명,γ-분비매재유지피부정상생리공능화제여염증성피부병、피부종류、감염성피부병、성병급결체조직병등다충피부질병중발휘중요작용.진관목전상무림상응용,γ-분비매적억제제화격활제가능재미래위피부병적예방화치료제공신적약물.
γ-Secretase,a transmembrane protease complex composed of four hydrophobic subunits,is capable of cleaving more than 30 type 1 transmembrane proteins such as β-amyloid precursor protein and Notch receptors.Recently,heterozygous mutations in the γ-secretase gene have been reported in multiple cases of familial and sporadic acne inversa.More and more data have highlighted γ-secretase to have a significant role in the maintenance of physiological function of normal skin and in the development of multiple skin diseases such as inflammatory dermatoses,skin tumors,infectious dermatoses,sexually transmitted diseases and connective tissue diseases.Although there has been no clinical practice,γ-secretase inhibitors and activators may open a new door in the prevention and treatment of skin diseases in the future.