中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2013年
9期
810-813
,共4页
张毅力%王苏弘%任艳玲%马岭%蔡婧%董选
張毅力%王囌弘%任豔玲%馬嶺%蔡婧%董選
장의력%왕소홍%임염령%마령%채청%동선
抽动障碍%持续注意%冲突检测%反应抑制
抽動障礙%持續註意%遲突檢測%反應抑製
추동장애%지속주의%충돌검측%반응억제
Tic disorder%Sustained attention%Conflict monitor%Response inhibition
目的 通过对抽动障碍(Tic Disorders,TD)患儿与正常儿童行为学及事件相关电位(Eventrelated Potentials,ERP)的比较分析,探索学龄期TD儿童持续注意与执行功能的特征.方法 选择TD患儿与正常儿童各30名,采用持续性操作测试记录行为学及ERP结果.结果 1.行为学:TD与正常儿童的击中数[分别为(38.07 ±3.04)、(38.93±1.48)]、反应时[分别为(465.427±97.00) ms、(500.17±131.29)ms]、遗漏错误数[分别为(1.97±3.02)、(1.07±1.48)]与虚报错误数[分别为(1.77±2.50)、(1.07±1.53)]均差异无统计学意义(P＞0.05).2.ERP:①N2波幅组别与条件的主效应、交互效应均显著(P＜0.05)；N2潜伏期组别与条件主效应、交互效应不均显著(P＞0.05).②P3波幅与潜伏期均条件的主效应显著(P＜0.05),组别的主效应、组别×条件的交互效应均不显著(P＞0.05).③抽动障碍儿童非靶N2波幅[(-1.39±3.32)]μV显著低于正常对照儿童[(-4.09±2.94)] μV(P＜0.05).结论 抽动障碍儿童任务的冲突监测可能存在损害,而持续注意与反应抑制能力与正常儿童相比无差异.
目的 通過對抽動障礙(Tic Disorders,TD)患兒與正常兒童行為學及事件相關電位(Eventrelated Potentials,ERP)的比較分析,探索學齡期TD兒童持續註意與執行功能的特徵.方法 選擇TD患兒與正常兒童各30名,採用持續性操作測試記錄行為學及ERP結果.結果 1.行為學:TD與正常兒童的擊中數[分彆為(38.07 ±3.04)、(38.93±1.48)]、反應時[分彆為(465.427±97.00) ms、(500.17±131.29)ms]、遺漏錯誤數[分彆為(1.97±3.02)、(1.07±1.48)]與虛報錯誤數[分彆為(1.77±2.50)、(1.07±1.53)]均差異無統計學意義(P＞0.05).2.ERP:①N2波幅組彆與條件的主效應、交互效應均顯著(P＜0.05)；N2潛伏期組彆與條件主效應、交互效應不均顯著(P＞0.05).②P3波幅與潛伏期均條件的主效應顯著(P＜0.05),組彆的主效應、組彆×條件的交互效應均不顯著(P＞0.05).③抽動障礙兒童非靶N2波幅[(-1.39±3.32)]μV顯著低于正常對照兒童[(-4.09±2.94)] μV(P＜0.05).結論 抽動障礙兒童任務的遲突鑑測可能存在損害,而持續註意與反應抑製能力與正常兒童相比無差異.
목적 통과대추동장애(Tic Disorders,TD)환인여정상인동행위학급사건상관전위(Eventrelated Potentials,ERP)적비교분석,탐색학령기TD인동지속주의여집행공능적특정.방법 선택TD환인여정상인동각30명,채용지속성조작측시기록행위학급ERP결과.결과 1.행위학:TD여정상인동적격중수[분별위(38.07 ±3.04)、(38.93±1.48)]、반응시[분별위(465.427±97.00) ms、(500.17±131.29)ms]、유루착오수[분별위(1.97±3.02)、(1.07±1.48)]여허보착오수[분별위(1.77±2.50)、(1.07±1.53)]균차이무통계학의의(P＞0.05).2.ERP:①N2파폭조별여조건적주효응、교호효응균현저(P＜0.05)；N2잠복기조별여조건주효응、교호효응불균현저(P＞0.05).②P3파폭여잠복기균조건적주효응현저(P＜0.05),조별적주효응、조별×조건적교호효응균불현저(P＞0.05).③추동장애인동비파N2파폭[(-1.39±3.32)]μV현저저우정상대조인동[(-4.09±2.94)] μV(P＜0.05).결론 추동장애인동임무적충돌감측가능존재손해,이지속주의여반응억제능력여정상인동상비무차이.
Objective To investigate behavior and electrophysiological manifestations of sustained attention and executive function in School-age children with tic disorder(TD).Methods Sixty-six school-aged children (36 TD and 30 control) participated in a CPT-AX task.Behavioral measures and ERP measures were collected.Results The 1.The Behavior results:there were no significant differences between the TD group and the control group in hitting number ((38.07 ± 3.04),(38.93 ± 1.48)),reaction time ((465.427 ± 97.00) ms,(500.17 ± 131.29) ms),the number of errors of omission((1.97 ± 3.02),(1.07 ± 1.48)) and the number of false errors ((1.77 ± 2.50),(1.07 ± 1.53)) (P ＞ 0.05).2.The ERP results:①Group and condition had significant main effect and interaction effect on N2 amplitude (P ＜ 0.05),while not on the latency of N2 (P ＞ 0.05).②Group had significant main effect on the amplitude and latency of P3,but main effect of Group and the interaction effect are not significant (P ＞ 0.05).③The TD group's amplitude of Nogo-N2 ((-1.39 ± 3.321) μV) were smaller than that of the control group ((-4.09 ± 2.94) μV) (P ＜ 0.05).Conclusion Children with TD performance impaired conflict monitor,while exhibit no deficits in sustained attention and response inhibition.
