CAJ | 학술논문

优化N-取代苯基四氢喹喔啉类化合物的合成工艺，考察各实验条件对关键中间体2-苯基-1，2-二氢喹喔啉合成的影响。设计最新合成路线；平行实验比较碳酸钠和乙酸钠对环合反应的影响，并对实验结果进行总体分析；对碳酸钠催化环合反应进行正交实验设计，考察反应温度和溶剂对收率的影响。结果显示：碳酸钠催化环合反应的收率较高，且易于处理；正交实验结果表明，以碳酸钠为催化剂，甲醇为溶剂进行室温反应，为环合反应的最优实验方案，收率达91．43％；新合成路线的总收率达67．64％。新合成方法步骤简单，条件温和，收率较高，适用于大量制备。
우화N-취대분기사경규악람류화합물적합성공예，고찰각실험조건대관건중간체2-분기-1，2-이경규악람합성적영향。설계최신합성로선；평행실험비교탄산납화을산납대배합반응적영향，병대실험결과진행총체분석；대탄산납최화배합반응진행정교실험설계，고찰반응온도화용제대수솔적영향。결과현시：탄산납최화배합반응적수솔교고，차역우처리；정교실험결과표명，이탄산납위최화제，갑순위용제진행실온반응，위배합반응적최우실험방안，수솔체91．43％；신합성로선적총수솔체67．64％。신합성방법보취간단，조건온화，수솔교고，괄용우대량제비。
To optimize Synthesis of N-substituted 3-benzyl-1,2,3,4-Tetrahydroquinoxaline derivatives and investi-gate the influence of experiment condition in the synthesis of key intermediate 2-benzyl-1,2-dihydroquinoxaline . Methods:A novel synthesis methods was designed;a parallel test was carried out to compare the catalytic activity of sodium carbonate and sodium acetate in cyclization reaction , including the total analysis of experimental result;And orthogonal experimental design was applied and the influence of temperature and solvent on the yield were in -vestigated .Results:The yield of the Sodium carbonate was higher than that of sodium acetate with easy effluent dis-posal, Orthogonal test confirms that Sodium carbonate used as catalyst , methanol as solvent in r .t.are the optimal experiment scheme and the yield is 91 .43%.The total yield is 67 .64%.Conclusion:the synthesized methods are much more available for large-scale preparation with easier procedure and higher yield .