CAJ | 학술논문

脂肪酸是食物脂质基本成分之一，不同种类脂肪酸对机体的细胞凋亡起不同作用。饱和脂肪酸可诱导胰岛β细胞、乳腺癌细胞、内皮细胞、神经细胞和生殖细胞等产生凋亡，而不饱和脂肪酸则可抑制凋亡。由于细胞凋亡发生的机制不尽相同，脂肪酸诱导凋亡或抑制凋亡的过程中就可能涉及细胞的不同信号通路，并且可能具有细胞特异性。对不同脂肪酸与细胞凋亡关系及其可能作用机制作一综述。
지방산시식물지질기본성분지일，불동충류지방산대궤체적세포조망기불동작용。포화지방산가유도이도β세포、유선암세포、내피세포、신경세포화생식세포등산생조망，이불포화지방산칙가억제조망。유우세포조망발생적궤제불진상동，지방산유도조망혹억제조망적과정중취가능섭급세포적불동신호통로，병차가능구유세포특이성。대불동지방산여세포조망관계급기가능작용궤제작일종술。
Fatty acids are one of the basic components of food lipids .Different kinds of fatty acids have different effects on apoptosis in the body .Saturated fatty acids can induce pancreatic βcells, breast cancer cells , endothelial cells, nerve cells and germ cells to apoptosis .However,the unsaturated fatty acid can inhibit apoptosis .Due to the various mechanisms of apoptosis , inductions or inhibitions of cellular apoptosis by fatty acids may involve different signaling pathways and may have cell specificity .In this article , we will review the effects and its possible mecha-nism of apoptosis induced by different fatty acids .