中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2014年
4期
416-418
,共3页
万美燕%张树俭%崔永军%隋小妮%于龙丽%邹作君
萬美燕%張樹儉%崔永軍%隋小妮%于龍麗%鄒作君
만미연%장수검%최영군%수소니%우룡려%추작군
腹膜透析%蛋白%丢失%心脏结构和功能
腹膜透析%蛋白%丟失%心髒結構和功能
복막투석%단백%주실%심장결구화공능
Peritoneal dialysis%Protein%Loss%Cardiac structure and function
目的:探讨糖尿病对腹膜透析(PD)患者腹透液蛋白丢失量及心脏结构与功能的影响。方法选择青岛市市立医院肾内科随访的腹膜透析治疗12个月的患者共68例,糖尿病患者32例,非糖尿病患者36例。测定2组患者腹膜透析前后生化指标,24 h腹透液蛋白量,以超声多普勒测定患者腹透前后左心房前后径(LAD)、左心室前后径(LVD)、室间隔厚度(IVST)、左室后壁厚度(LVPWT)及左心室射血分数(LVEF)等,并进行比较。结果腹膜透析治疗前,糖尿病组与非糖尿病组患者各指标无差异。腹膜透析治疗1年后,两组患者在血清白蛋白、腹透液蛋白丢失量、室间隔厚度(IVST)、左室后壁厚度(LVPWT)及左心室射血分数(LVEF)等指标有统计学差异(P<0.05)。腹透液蛋白丢失量:腹透液蛋白丢失量与血浆白蛋白及LVEF呈负相关关系(r=-0.476,P<0.01;r=-0.269,P<0.05);与IVST、LVPWT呈正相关关系(r=0.461,P<0.01;r=0.346,P<0.01)。结论糖尿病腹膜透析患者的腹透液蛋白丢失量更大,并会进一步影响患者的心脏结构和功能。
目的:探討糖尿病對腹膜透析(PD)患者腹透液蛋白丟失量及心髒結構與功能的影響。方法選擇青島市市立醫院腎內科隨訪的腹膜透析治療12箇月的患者共68例,糖尿病患者32例,非糖尿病患者36例。測定2組患者腹膜透析前後生化指標,24 h腹透液蛋白量,以超聲多普勒測定患者腹透前後左心房前後徑(LAD)、左心室前後徑(LVD)、室間隔厚度(IVST)、左室後壁厚度(LVPWT)及左心室射血分數(LVEF)等,併進行比較。結果腹膜透析治療前,糖尿病組與非糖尿病組患者各指標無差異。腹膜透析治療1年後,兩組患者在血清白蛋白、腹透液蛋白丟失量、室間隔厚度(IVST)、左室後壁厚度(LVPWT)及左心室射血分數(LVEF)等指標有統計學差異(P<0.05)。腹透液蛋白丟失量:腹透液蛋白丟失量與血漿白蛋白及LVEF呈負相關關繫(r=-0.476,P<0.01;r=-0.269,P<0.05);與IVST、LVPWT呈正相關關繫(r=0.461,P<0.01;r=0.346,P<0.01)。結論糖尿病腹膜透析患者的腹透液蛋白丟失量更大,併會進一步影響患者的心髒結構和功能。
목적:탐토당뇨병대복막투석(PD)환자복투액단백주실량급심장결구여공능적영향。방법선택청도시시립의원신내과수방적복막투석치료12개월적환자공68례,당뇨병환자32례,비당뇨병환자36례。측정2조환자복막투석전후생화지표,24 h복투액단백량,이초성다보륵측정환자복투전후좌심방전후경(LAD)、좌심실전후경(LVD)、실간격후도(IVST)、좌실후벽후도(LVPWT)급좌심실사혈분수(LVEF)등,병진행비교。결과복막투석치료전,당뇨병조여비당뇨병조환자각지표무차이。복막투석치료1년후,량조환자재혈청백단백、복투액단백주실량、실간격후도(IVST)、좌실후벽후도(LVPWT)급좌심실사혈분수(LVEF)등지표유통계학차이(P<0.05)。복투액단백주실량:복투액단백주실량여혈장백단백급LVEF정부상관관계(r=-0.476,P<0.01;r=-0.269,P<0.05);여IVST、LVPWT정정상관관계(r=0.461,P<0.01;r=0.346,P<0.01)。결론당뇨병복막투석환자적복투액단백주실량경대,병회진일보영향환자적심장결구화공능。
Objective To investigate the influences of diabetes and dialysate protein loss on cardiac structure and heart function in patients treated with peritoneal dialysis (PD). Methods The patients (n=68) treated with PD for 12 m were chosen, and among them 32 with and 36 without diabetes (diabetes group and non-diabetes group). The biochemical indexes and 24-h dialysate protein quantity were detected in 2 groups before and after PD. The changes of LAD, LVD, IVST, LVPWT and LVEF were detected and compared by using color Doppler ultrasound before and after PD. Results All indexes had no statistical difference in 2 groups before PD. After PD for 1 y, there was difference in serum albumin, dialysate protein loss, IVST, LVPWT and LVEF between 2 groups (P<0.05). The correlation analysis showed that dialysate protein loss was negatively correlated to serum albumin and LVEF (r=-0.476, P<0.01;r=-0.269, P<0.05), and positively correlated to IVST and LVPWT (r=0.461, P<0.01;r=0.346, P<0.01). Conclusion Dialysate protein loss will increase in diabetic patients after PD, which can further influence patient’s cardiac structure and heart function.