CAJ | 학술논문

目的：分析国人主动脉夹层（AD）发病危险因素的流行病学特征。方法回顾性分析2011年1月1日至2012年12月31日国内15家大型心脏中心的1015例AD患者资料。AD患者为病例组。选取同期在该院住院并排除AD的920例患者为对照组。收集患者年龄、性别、体质指数（BMI）、白塞氏病、高血压、血脂、动脉粥样硬化等方面的资料。结果高血压、马凡综合征、白塞氏病、吸烟、饮酒、单纯性肾囊肿、主动脉二瓣化畸形、动脉粥样硬化、FFA、UA是AD发病的独立危险因素。高血压OR值为9.068，提示高血压与AD发病相关性较强。ApoA-I（OR：0.173，95%CI：2.56~12.79）及HDL-C（OR：0.122，95%CI：4.57~9.26）为AD的保护性因素。结论高血压、马凡综合征、吸烟、饮酒、单纯性肾囊肿、主动脉瓣二瓣化畸形、动脉粥样硬化、UA和FFA是国人AD发病的独立危险因素，ApoA-I和HDL-C为AD的保护因素。临床医生应对危险因素予以关注。
목적：분석국인주동맥협층（AD）발병위험인소적류행병학특정。방법회고성분석2011년1월1일지2012년12월31일국내15가대형심장중심적1015례AD환자자료。AD환자위병례조。선취동기재해원주원병배제AD적920례환자위대조조。수집환자년령、성별、체질지수（BMI）、백새씨병、고혈압、혈지、동맥죽양경화등방면적자료。결과고혈압、마범종합정、백새씨병、흡연、음주、단순성신낭종、주동맥이판화기형、동맥죽양경화、FFA、UA시AD발병적독립위험인소。고혈압OR치위9.068，제시고혈압여AD발병상관성교강。ApoA-I（OR：0.173，95%CI：2.56~12.79）급HDL-C（OR：0.122，95%CI：4.57~9.26）위AD적보호성인소。결론고혈압、마범종합정、흡연、음주、단순성신낭종、주동맥판이판화기형、동맥죽양경화、UA화FFA시국인AD발병적독립위험인소，ApoA-I화HDL-C위AD적보호인소。림상의생응대위험인소여이관주。
Objective To analyze the epidemiological characteristics of risk factors of attack of aortic dissection disease (AD) in Chinese population. Methods The data of 1015 AD patients were retrospectively analyzed in 15 large-scale cardiologic centers from Jan. 1, 2011 to Dec. 31, 2012. AD patients were included into case group and 920 patients without AD at the same hospitalization time were included into control group. The data related to age, sex, body mass index (BMI), Behcet’s disease (BD), hypertension, blood fat and atherosclerosis was collected. Results Hypertension, Marfan’s syndrome, BD, smoking, drinking, simple renal cyst, bicuspid aortic valve, atherosclerosis, free fatty acid (FFA) and uric acid (UA) were independent risk factors of AD attack. The OR value of hypertension was 9.068, which indicated that hypertension was closely correlated to AD attack. ApoA-I (OR:0.173, 95%CI:2.56~12.79) and HDL (OR:0.122, 95%CI:4.57~9.26) were protective factors of AD attack. Conclusion Hypertension, Marfan’s syndrome, smoking, drinking, simple renal cyst, bicuspid aortic valve, atherosclerosis, UA and FFA are independent risk factors of AD attack in Chinese population, and ApoA-I and HDL are protective factors. The clinical doctors should pay attention to these risk factors.