CAJ | 학술논문

建立了液相色谱-串联质谱联用测定化妆品中3种芦荟蒽醌类化合物含量的方法。样品经甲醇超声提取，用高效液相色谱分离后，采用电喷雾串联质谱进行定性和定量检测。方法线性范围为10～100 ng/mL，相关系数r大于0．99，最低检出限为3 ng/mL（S/N＝3），高、中、低3个浓度水平的加标回收率在80．4％～95．2％之间，测定值的相对标准偏差（n＝6）小于10％。
건립료액상색보-천련질보련용측정화장품중3충호회은곤류화합물함량적방법。양품경갑순초성제취，용고효액상색보분리후，채용전분무천련질보진행정성화정량검측。방법선성범위위10～100 ng/mL，상관계수r대우0．99，최저검출한위3 ng/mL（S/N＝3），고、중、저3개농도수평적가표회수솔재80．4％～95．2％지간，측정치적상대표준편차（n＝6）소우10％。
A sensitive method for determination of three anthraquinone compounds in cosmetics by liquid chromatography tan-dem mass spectrometry(LC-MS/MS)was established. The cosmetics sample was ultrasonically extracted by methanol,then was separated and determined by HPLC-ESI-MS/MS. A linear calibration curve was obtained in the concentration range of 10 to 100 ng/mL. The linear correlation coefficients of the method were above 0.99. The detection limit of method was 3 ng/mL (S/N= 3). The recoveries at three levels ranged from 80.4% to 95.2% ,with the relative standard deviation (n= 6)of less than 1 0% .