现代泌尿生殖肿瘤杂志
現代泌尿生殖腫瘤雜誌
현대비뇨생식종류잡지
JOURNAL OF CONTEMPORARY UROLOGIC AND REPRODUCTIVE ONCOLOGY
2014年
4期
231-234
,共4页
郭巍%陈美霓%贺晓龙%高继学%张烨%李义%张鸿毅%贾军琪%强亚勇%宋红雄%白安胜
郭巍%陳美霓%賀曉龍%高繼學%張燁%李義%張鴻毅%賈軍琪%彊亞勇%宋紅雄%白安勝
곽외%진미예%하효룡%고계학%장엽%리의%장홍의%가군기%강아용%송홍웅%백안성
前列腺肿瘤%HIF-1α%VEGF-C%VEGFR-3
前列腺腫瘤%HIF-1α%VEGF-C%VEGFR-3
전렬선종류%HIF-1α%VEGF-C%VEGFR-3
Prostatic neoplasms%HIF-1α%VEGF-C%VEGFR-3
目的：探讨缺氧诱导因子-1α(hypoxia inducible factor-1,HIF-1α)、血管内皮生长因子-C(vascular endothelial growth factor-C,VEGF-C)和 VEGF 受体-3(vascular endothelial growth factor receptor-3,VEGFR-3)蛋白在前列腺癌组织中的表达及意义。方法应用免疫组织化学SP 法测定64例前列腺癌和15例正常前列腺组织中 HIF-1α、VEGF-C 和 VEGFR-3蛋白的表达情况。结果 HIF-1α、VEGF-C 和 VEGFR-3蛋白在前列腺癌组织中的表达率分别为60.9%、70.3%和71.9%,在正常前列腺组织中均无表达；HIF-1α蛋白的表达与病理分级、临床分期和淋巴转移有关,VEGF-C 蛋白与病理分级和淋巴转移有关,VEGFR-3蛋白与淋巴转移有关(P <0.05)；在前列腺癌组织中 HIF-1α与 VEGF-C、VEGFR-3；VEGF-C 与 VEGFR-3的表达呈正相关(P <0.05)。结论前列腺癌组织中 HIF-1α、VEGF-C 和 VEGFR-3蛋白的高表达与前列腺癌的发生及淋巴转移相关。
目的：探討缺氧誘導因子-1α(hypoxia inducible factor-1,HIF-1α)、血管內皮生長因子-C(vascular endothelial growth factor-C,VEGF-C)和 VEGF 受體-3(vascular endothelial growth factor receptor-3,VEGFR-3)蛋白在前列腺癌組織中的錶達及意義。方法應用免疫組織化學SP 法測定64例前列腺癌和15例正常前列腺組織中 HIF-1α、VEGF-C 和 VEGFR-3蛋白的錶達情況。結果 HIF-1α、VEGF-C 和 VEGFR-3蛋白在前列腺癌組織中的錶達率分彆為60.9%、70.3%和71.9%,在正常前列腺組織中均無錶達；HIF-1α蛋白的錶達與病理分級、臨床分期和淋巴轉移有關,VEGF-C 蛋白與病理分級和淋巴轉移有關,VEGFR-3蛋白與淋巴轉移有關(P <0.05)；在前列腺癌組織中 HIF-1α與 VEGF-C、VEGFR-3；VEGF-C 與 VEGFR-3的錶達呈正相關(P <0.05)。結論前列腺癌組織中 HIF-1α、VEGF-C 和 VEGFR-3蛋白的高錶達與前列腺癌的髮生及淋巴轉移相關。
목적：탐토결양유도인자-1α(hypoxia inducible factor-1,HIF-1α)、혈관내피생장인자-C(vascular endothelial growth factor-C,VEGF-C)화 VEGF 수체-3(vascular endothelial growth factor receptor-3,VEGFR-3)단백재전렬선암조직중적표체급의의。방법응용면역조직화학SP 법측정64례전렬선암화15례정상전렬선조직중 HIF-1α、VEGF-C 화 VEGFR-3단백적표체정황。결과 HIF-1α、VEGF-C 화 VEGFR-3단백재전렬선암조직중적표체솔분별위60.9%、70.3%화71.9%,재정상전렬선조직중균무표체；HIF-1α단백적표체여병리분급、림상분기화림파전이유관,VEGF-C 단백여병리분급화림파전이유관,VEGFR-3단백여림파전이유관(P <0.05)；재전렬선암조직중 HIF-1α여 VEGF-C、VEGFR-3；VEGF-C 여 VEGFR-3적표체정정상관(P <0.05)。결론전렬선암조직중 HIF-1α、VEGF-C 화 VEGFR-3단백적고표체여전렬선암적발생급림파전이상관。
Objective The study was to investigate the expression and clinical significance of HIF-1α,VEGF-C and VEGFR-3 protein in prostate cancer. Methods The expression of HIF-1α,VEGF-C and VEGFR-3 protein was detected by means of immunohistochemical staining in 64 prostate cancer and 15 normal prostate tissue specimens. Results The positive rates of HIF-1α,VEGF-C and VEGFR-3 protein were 60.9%,70.3%,71.9% in prostate cancer respectively,and there was no expression in normal prostate tissue.The expression of HIF-1αwas associated with histological grade,clinical sta-ges and lymph node metastasis;The expression of VEFG-C was associated with histological grade and lymph node metastasis;The expression of VEGFR-3 was associated with lymph node metastasis (P <0.05).The expression of HIF-1α was positively associated with VEGF-C and VEGFR-3,and expression of VEGF-C was positively associated with VEGFR-3 (P <0.05). Conclusions The ex-pression of HIF-1α,VEGF-C and VEGFR-3 proteins were up-regulated in prostate cancer,which might be relate to tumorigenesis and the development of prostate cancer.
