CAJ | 학술논문

目的：探讨前列腺癌基因3(prostate cancer gene 3,PCA3)和多参数磁共振成像(multiparametric magnetic resonance imaging,mMRI)对前列腺癌的诊断意义。方法对56例首次穿刺结果为阴性但 PSA 持续升高的患者在第二次穿刺活检之前行 PCA3和 mMRI 检查。评估 PCA3评分和 mMRI 对前列腺癌诊断的准确性和可靠度及其对前列腺穿刺结果的预测性。结果 mMRI 结果显示20例(35.7%)患者具有前列腺癌特征；PCA3评分(截断值为35时)显示15例(26.8%)患者疑为前列腺癌；前列腺穿刺活检结果显示23例(41.1%)患者确诊为前列腺癌。PCA3和 mMRI 对前列腺癌诊断的敏感性和特异性分别为67%、49%及74%、89%。结论 mMRI 增加了PCA3对前列腺癌诊断的准确性和敏感性,可以减少不必要的前列腺穿刺。
목적：탐토전렬선암기인3(prostate cancer gene 3,PCA3)화다삼수자공진성상(multiparametric magnetic resonance imaging,mMRI)대전렬선암적진단의의。방법대56례수차천자결과위음성단 PSA 지속승고적환자재제이차천자활검지전행 PCA3화 mMRI 검사。평고 PCA3평분화 mMRI 대전렬선암진단적준학성화가고도급기대전렬선천자결과적예측성。결과 mMRI 결과현시20례(35.7%)환자구유전렬선암특정；PCA3평분(절단치위35시)현시15례(26.8%)환자의위전렬선암；전렬선천자활검결과현시23례(41.1%)환자학진위전렬선암。PCA3화 mMRI 대전렬선암진단적민감성화특이성분별위67%、49%급74%、89%。결론 mMRI 증가료PCA3대전렬선암진단적준학성화민감성,가이감소불필요적전렬선천자。
Objective To evaluate the value of the urinary prostate cancer gene 3 (PCA3)as-say combining multiparametric magnetic resonance imaging (mMRI)in diagnosis of prostate cancer (PCa). Methods A study of 56 patients with a longlasting high prostate-specific antigen level and previously negative biopsy was performed to assess the role of mMRI and PCA3 in identifying PCa, the accuracy and reliability were evaluated. Results mMRI showed that 20(35.7%)patients were may sufferer PCa;And PCA3 scores showed that 15(26.8%)cases may suffer from PCa;Repeated tran-srectal ultrasound(TRUS)-guided biopsy identified 23 (41.1%)new cases of PCa.The sensitivity and specificity of PCA3 test and mMRI was 67% and 49% and 74% and 89%,respectively.The study showed that the model included mMRI and PCA3 had a better performance in predicting PCa. Conclusions mMRI can improve the accuracy and sensitivity of PCA3 for diagnosis of PCa,there-fore,can avoid unnecessary biopsies.