CAJ | 학술논문

目的：了解广东省惠州地区流动人口育龄妇女人乳头瘤病毒（ human papillomavirus ，HPV）感染、分型及宫颈病变的现况，分析感染、HPV型别与宫颈病变程度的关系。方法对7796例已婚育龄妇女进行HPV-DNA检测和分型，对HPV阳性者进行宫颈液基薄层细胞学（ thinprep cytology test ， TCT）检测，对检测结果进行分析。结果7796例受检对象中共检出HPV感染568例（7.29％），以HPV16、58、52、18型多见。25岁以下女性HPV感染阳性率最高（15.97％），高于其他年龄组（P＜0.05）。对568例HPV感染者进行TCT筛查， ASCUS级以上宫颈病变298例（52.46％）。结论广东省惠州地区流动人口育龄妇女HPV感染主要感染类型为HPV16、58、52、18型，感染者年龄以15～24岁人群最高，宫颈病变发生率及病变程度随感染者年龄增加而升高。定期筛查HPV感染，尤其高龄感染者是早期发现宫颈病变和预防宫颈癌的重要手段。
목적：료해광동성혜주지구류동인구육령부녀인유두류병독（ human papillomavirus ，HPV）감염、분형급궁경병변적현황，분석감염、HPV형별여궁경병변정도적관계。방법대7796례이혼육령부녀진행HPV-DNA검측화분형，대HPV양성자진행궁경액기박층세포학（ thinprep cytology test ， TCT）검측，대검측결과진행분석。결과7796례수검대상중공검출HPV감염568례（7.29％），이HPV16、58、52、18형다견。25세이하녀성HPV감염양성솔최고（15.97％），고우기타년령조（P＜0.05）。대568례HPV감염자진행TCT사사， ASCUS급이상궁경병변298례（52.46％）。결론광동성혜주지구류동인구육령부녀HPV감염주요감염류형위HPV16、58、52、18형，감염자년령이15～24세인군최고，궁경병변발생솔급병변정도수감염자년령증가이승고。정기사사HPV감염，우기고령감염자시조기발현궁경병변화예방궁경암적중요수단。
Objective To investigate the epidemiology about the women of childbearing age with human papillomavirus ( HPV) infection and cervical lesions among floating population in Huizhou of Guangdong province .To analyzetherelationshipbetweenHPVinfection,typeofHPVandcervicallesions.Methods 7796marriedwomen were undergone the HPV-DNA test.Thinprep cytology test(TCT) were conducted in HPV positive cases .Results 568HPVinfectionswerefoundin7796caseswithainfectionrateof7.29%.AmongallthetypesofHPV,type 16, 58, 52, 18 were in common.Women less than 25 years old had the highest positive rates of HPV infection (15.97%) with a statistical significant difference (P<0.05).In 568 cases with HPV infection, the TCT screening showed that 289 cases were found abnormal above ASCUS (52.46%) .Conclusions The women of childbearing age with HPV infection among floating population in Huizhou are mainly of type 16, 58, 52, 18 and 15~24 years old cases.The incidence rate and lesion severity of cervical lesions increased as the age goes up .Regular screening of HPV infection is an important method to discover cervical lesions in early stage and to prevent cervical cancer especially in older infected women .