CAJ | 학술논문

[目的]观察益骨口服液对去势大鼠骨质疏松症痛阈及骨密度的影响。[方法]将84只SD大鼠随机分益骨口服液组、密盖息组、益骨口服液及密盖息联合组、生理盐水对照组，每组各21只；造模成功后,分别予益骨口服液、密盖息、益骨口服液及密盖息、生理盐水等不同药物灌胃,于治疗后第10d、第30d、第60d、第90d四个时点分别测量各组大鼠痛阈、股骨骨密度。[结果]治疗第10d、30d、60d、90d益骨口服液组、密盖息组、益骨口服液及密盖息联合组与对照组相比，去势大鼠痛阈明显升高，差异有统计学意义(P<0.05)。治疗第10d、30d，益骨口服液组、密盖息组、益骨口服液及密盖息联合组股骨骨密度与对照组相比，差异无统计学意义(P>0.05),在治疗第60d、90d时，骨密度明显提高差异有统计学意义(P<0.05)。[结论]益骨口服液能提高去势大鼠痛阈、骨密度，从而减轻骨质疏松大鼠疼痛。
[목적]관찰익골구복액대거세대서골질소송증통역급골밀도적영향。[방법]장84지SD대서수궤분익골구복액조、밀개식조、익골구복액급밀개식연합조、생리염수대조조，매조각21지；조모성공후,분별여익골구복액、밀개식、익골구복액급밀개식、생리염수등불동약물관위,우치료후제10d、제30d、제60d、제90d사개시점분별측량각조대서통역、고골골밀도。[결과]치료제10d、30d、60d、90d익골구복액조、밀개식조、익골구복액급밀개식연합조여대조조상비，거세대서통역명현승고，차이유통계학의의(P<0.05)。치료제10d、30d，익골구복액조、밀개식조、익골구복액급밀개식연합조고골골밀도여대조조상비，차이무통계학의의(P>0.05),재치료제60d、90d시，골밀도명현제고차이유통계학의의(P<0.05)。[결론]익골구복액능제고거세대서통역、골밀도，종이감경골질소송대서동통。
Objective] To observe the influence of YIGU oral liquid on the pain threshold and bone mineral density in ovariectomized rats. [Methods] Eighty-four Female SD rats were randomly divided into 4groups:YIGU oral liquid group, calcitonin group,YIGU oral liquid combined with calcitonin group, saline control group.The ovariectomized rats were confirmed the successful model of osteoporosis,rats in the YIGU oral liquid group were administered with YIGU oral liquid, rats in the calcitonin group were administered with calcitonin, rats in the YIGU oral liquid combined with calcitonin group were administered with YIGU oral liquid group and calcitonin,rats in the saline control group were administered with saline.To detect the pain threshold and bone mineral density at the 10th day, 30th day, 60th day and 90th day respectively. [Results]At the 10th, 30th, 60th and 90th day after treatment, the pain threshold of the YIGU oral liquid group, calcitonin group,YIGU oral liquid combined with calcitonin group compare to saline control group, there was significant statistical difference( P<0.05).At the 10th, 30th day after treatment,the bone mineral density of the YIGU oral liquid group, cal-citonin group,YIGU oral liquid combined with calcitonin group compared with saline control group, there was no significant statistical difference( P>0.05). At the 60th,90th day after treatment, there was significant statistical difference( P<0.05).[Conclusion] YIGU oral liquid can effectively enhance pain thresh-old and bone mineral density of the ovariectomized rats to inhibit the osteoporosis pain.