CAJ | 학술논문

目的：探讨乳腺肿瘤中CerbB-2基因表达与彩色血管能量成像（CPA）的诊断价值及其相关性。方法术前应用超声CPA多普勒技术常规检测49例乳腺癌患者及30例乳腺纤维腺瘤患者的肿瘤血流信号，与免疫组化法检测CerbB-2的基因表达情况做对照，并分析其相关性。结果49例乳腺癌CerbB-2基因表达阳性率（71％）高于乳腺纤维腺瘤组（33．3％，P ＜0．05），CerbB-2在临床Ⅲ、Ⅳ期的阳性表达率（83．3％）显著高于其在Ⅰ、Ⅱ期的表达率（50％，P ＜0.01），伴有淋巴转移者CerbB-2基因的表达率为86．7％，无淋巴结者阳性表达率为45％，两者比较有统计学意义（ P ＜0.01）。CerbB-2的表达强度与CPA血流分级呈正相关（γ＝0．683，P ＜0．01）。结论 CerbB-2基因在乳腺癌中呈高强度表达，且与CPA血流的分级呈正相关，两者联合评价乳腺肿瘤能为临床早期诊断和预后评估提供重要信息。
목적：탐토유선종류중CerbB-2기인표체여채색혈관능량성상（CPA）적진단개치급기상관성。방법술전응용초성CPA다보륵기술상규검측49례유선암환자급30례유선섬유선류환자적종류혈류신호，여면역조화법검측CerbB-2적기인표체정황주대조，병분석기상관성。결과49례유선암CerbB-2기인표체양성솔（71％）고우유선섬유선류조（33．3％，P ＜0．05），CerbB-2재림상Ⅲ、Ⅳ기적양성표체솔（83．3％）현저고우기재Ⅰ、Ⅱ기적표체솔（50％，P ＜0.01），반유림파전이자CerbB-2기인적표체솔위86．7％，무림파결자양성표체솔위45％，량자비교유통계학의의（ P ＜0.01）。CerbB-2적표체강도여CPA혈류분급정정상관（γ＝0．683，P ＜0．01）。결론 CerbB-2기인재유선암중정고강도표체，차여CPA혈류적분급정정상관，량자연합평개유선종류능위림상조기진단화예후평고제공중요신식。
Objective To analyse the correlation of the CPA of ultrasound with the expression of CerbB-2 and its clinical value in breast tumor .Methods Preoperatively ,the blood flow signal of 49 patients with breast carcinoma and 30 cases with breast fibro-adenoma were measured by CPA .The correlation of the expressions of their CerbB-2 gene were detected with immunohistochemistry post-operation .Results The positive expression rate (71% ) of CerbB-2 of the breast carcino-ma was higher than that of breast fibro-adenoma (33 .5% ) .The CerbB-2 positive expression rate (83 .3% ) of breast carci-noma in clinical stages Ⅲ to Ⅳ ,was significantly higher than that of the stages of Ⅰ to Ⅱ (50% ) .The positive rate of breast carcinoma with lymph nodes metastasis was 86 .7% ,while 45% was found in non-metastasis .The comparison be-tween these two groups revealed a significant difference .The expressive intensity of CerbB-2 had a positive correlation to the degrees of CPA flow (γ=0 .683 ,P < 0 .01) .Conclusion The high expressions of CerbB-2 in breast carcinoma were positively correlated to the CPA flow degree .CerbB-2 and CPA may provide important information for the earlier diagnosis and judgment .