医学影像学杂志
醫學影像學雜誌
의학영상학잡지
JOURNAL OF MEDICAL IMAGING
2014年
8期
1285-1288
,共4页
放射学%介入性%125 I放射粒子%近距离放射治疗%鼻窦复发性恶性肿瘤
放射學%介入性%125 I放射粒子%近距離放射治療%鼻竇複髮性噁性腫瘤
방사학%개입성%125 I방사입자%근거리방사치료%비두복발성악성종류
Interventional radiology%Particles 125 I brachytherapy%Paranasal sinus recurrent tumor
目的：探讨C T引导下植入125 I放射粒子治疗鼻窦复发性恶性肿瘤的方法、疗效、安全性。方法11例鼻窦复发性恶性肿瘤患者，行C T引导下经皮穿刺植入125 I放射粒子。术前应用放射粒子近距离治疗计划系统，计划125 I放射粒子的活度和用量，粒子活度为0．6～0．8mCi ，术后立即行CT扫描并进行质量验证，定期CT随访，判定分析疗效。结果11例鼻窦复发性恶性肿瘤患者，均按计划完成治疗，分别于术后2、4、6、12月复查C T ，肿瘤局部控制有效率（RR ）依次是：100％（11/11）、100％（11/11）、90．9％（10/11）、81．8％（9/11）；3例在植入部位骨破坏区出现了明显的骨化，占27.3％（3/11），6月后行再次植入补充治疗1例，治疗后1月出现皮肤色素沉着6例，未发生皮肤溃疡。结论 CT 引导下植入125 I放射粒子治疗鼻窦复发性恶性肿瘤，疗效可靠、并发症轻，值得进一步应用研究。
目的：探討C T引導下植入125 I放射粒子治療鼻竇複髮性噁性腫瘤的方法、療效、安全性。方法11例鼻竇複髮性噁性腫瘤患者，行C T引導下經皮穿刺植入125 I放射粒子。術前應用放射粒子近距離治療計劃繫統，計劃125 I放射粒子的活度和用量，粒子活度為0．6～0．8mCi ，術後立即行CT掃描併進行質量驗證，定期CT隨訪，判定分析療效。結果11例鼻竇複髮性噁性腫瘤患者，均按計劃完成治療，分彆于術後2、4、6、12月複查C T ，腫瘤跼部控製有效率（RR ）依次是：100％（11/11）、100％（11/11）、90．9％（10/11）、81．8％（9/11）；3例在植入部位骨破壞區齣現瞭明顯的骨化，佔27.3％（3/11），6月後行再次植入補充治療1例，治療後1月齣現皮膚色素沉著6例，未髮生皮膚潰瘍。結論 CT 引導下植入125 I放射粒子治療鼻竇複髮性噁性腫瘤，療效可靠、併髮癥輕，值得進一步應用研究。
목적：탐토C T인도하식입125 I방사입자치료비두복발성악성종류적방법、료효、안전성。방법11례비두복발성악성종류환자，행C T인도하경피천자식입125 I방사입자。술전응용방사입자근거리치료계화계통，계화125 I방사입자적활도화용량，입자활도위0．6～0．8mCi ，술후립즉행CT소묘병진행질량험증，정기CT수방，판정분석료효。결과11례비두복발성악성종류환자，균안계화완성치료，분별우술후2、4、6、12월복사C T ，종류국부공제유효솔（RR ）의차시：100％（11/11）、100％（11/11）、90．9％（10/11）、81．8％（9/11）；3례재식입부위골파배구출현료명현적골화，점27.3％（3/11），6월후행재차식입보충치료1례，치료후1월출현피부색소침착6례，미발생피부궤양。결론 CT 인도하식입125 I방사입자치료비두복발성악성종류，료효가고、병발증경，치득진일보응용연구。
Objective To investigate the method ,efficacy and safety of radioactive particle 125 I implantation by CT guid-ance in treatment of recurrent malignant tumor in paranasal sinuses .Methods 11 cases of recurrent malignant tumor in paranasal sinuses were subjected to percutaneous implantation of radioactive particle 125 I under the CT guidance .Preopera-tively ,the lesion contour and size were ovbserved by use of radioactive seed brachytherapy treatment planning system (brachy interstitial-therapy planning system ,BI-TPSTM ) .The radioactivity and dosage of particle 125 I were calculated . The prescription dose (prescribed dose ,PD) was 110~140 Gy and particle activity was 0 .6~0 .8 mCi .Postoperatively , CT scan was immediately performed and the quality was validated .The regular CT cllow-up was conducted to determine curative effect .Results 11 patients with maxillofacial recurrent malignant tumors were completely accepted the treatment planning and underwent CT re-examination at 2 months ,4 months ,6 months ,and 12 months after operation ,respective-ly .The local tumor control rate (RR) was 100% (11/11) ,100% (11/11) ,90 .9% (10/11) ,81 .8% (9/11) in order of the indicated time points .3 cases appeared obvious ossification in destroyed bone area at the implanted site ,accounting for 27.3% (3/11) .One patient was implanted once more 6 months later .6 patients appeared skin pigmentation one month af-ter the treatment .Conclusion Radioactive particle 125 I implantation guided by CT is simple ,reliable curative effect ,high safety in treatment of recurrent malignant tumor in paranasal sinus .It is worthy for further application research .
