CAJ | 학술논문

细胞间黏附分子（Intercellular adhesion molecule，ICAM）是一类具有介导细胞与细胞、细胞与细胞外基质间黏附作用的生物大分子，多分布于细胞表面或细胞外基质。其在胚胎的发育分化、正常组织结构的维持、炎症与免疫应答、以及肿瘤的进展和转移等多种生理病理过程中均具有重要作用。近年来，ICAM-1（Intercellular adhesion molecule-1）作为免疫球蛋白超家族中的一员在牙周炎中的作用逐渐得到关注。在牙周致病菌的刺激下，ICAM-1可表达于牙周上皮细胞、成纤维细胞以及内皮细胞，并参与白细胞的趋化、黏附、迁移及增殖，从而使白细胞聚集于炎症部位，释放出大量炎性介质，最终导致对牙周组织的破坏。本文从ICAM-1在牙周组织中的表达分布、表达途径及其调节等方面对ICAM-1与牙周炎的关系作一综述。
세포간점부분자（Intercellular adhesion molecule，ICAM）시일류구유개도세포여세포、세포여세포외기질간점부작용적생물대분자，다분포우세포표면혹세포외기질。기재배태적발육분화、정상조직결구적유지、염증여면역응답、이급종류적진전화전이등다충생리병리과정중균구유중요작용。근년래，ICAM-1（Intercellular adhesion molecule-1）작위면역구단백초가족중적일원재아주염중적작용축점득도관주。재아주치병균적자격하，ICAM-1가표체우아주상피세포、성섬유세포이급내피세포，병삼여백세포적추화、점부、천이급증식，종이사백세포취집우염증부위，석방출대량염성개질，최종도치대아주조직적파배。본문종ICAM-1재아주조직중적표체분포、표체도경급기조절등방면대ICAM-1여아주염적관계작일종술。
Intercellularadhesionmolecule(ICAM)isaclassofbiologicalmacromoleculesoncellsurface or in extracellular matrix,which mediate adhesion of cell-cell and cell-extracellular matrix.ICAMs play a very impor-tant role in a variety of physiological and pathological processes such as the embryonic development and cell differentia-tion,the maintenance of normal tissue structure,inflammation and immune response,tumor progression and so on.Re-cently,as a member of the immunoglobulin superfamily,infercellular adhesion molecule-1 (ICAM-1 )in periodontitis gradually catches attention.The expression ICAM-1 on periodontal epithelial cells,fibroblasts and endothelial cells might be upregulated in response to the stimulation of periodontal pathogens in periodontal tissues,which contributes to chemotaxis,adhesion,migration and proliferation of leukocytes,resulting in leukocyte aggregation and subsequent in-flammatory cytokine release.This article summarizes the role of ICAM-1 in periodontitis.