CAJ | 학술논문

Matrigel是一种从Engelbreth-Holm-Swarm（ EHS）小鼠肉瘤中提取的可溶性基底膜成分，其主要成分包括层粘连蛋白、Ⅳ型胶原、巢蛋白、硫酸肝素糖蛋白和各种细胞因子。上皮来源的肿瘤含有丰富的基底膜，并在肿瘤生长、转移和形态等方面表现出独特的作用。 Matrigel已广泛用于肿瘤研究中，本文阐述了matrigel在肿瘤体内外实验模型中的应用。研究matrigel将有助于我们加深对肿瘤本质的认识并提供更为有效的治疗靶点。
Matrigel시일충종Engelbreth-Holm-Swarm（ EHS）소서육류중제취적가용성기저막성분，기주요성분포괄층점련단백、Ⅳ형효원、소단백、류산간소당단백화각충세포인자。상피래원적종류함유봉부적기저막，병재종류생장、전이화형태등방면표현출독특적작용。 Matrigel이엄범용우종류연구중，본문천술료matrigel재종류체내외실험모형중적응용。연구matrigel장유조우아문가심대종류본질적인식병제공경위유효적치료파점。
Matrigel ,a tumor rich extracellular matrix protein ,is a soluble basement membrane composition extrac-ted from the Engelbreth-Holm-Swarm mouse sarcoma.It is mainly comprised of laminin ,collagen IV,heparan sulfate proteoglycans ,entactin/nidogen and various growth factors.A large body of evidence demonstrates that matrigel plays a significant role in the tumor development ,metastasis and morphology.We summarized the role of matrigel in cancer research in vivo and in vitro , which will help us to deepen the understanding of the essence of tumor and pravide more effective therapeutic targets.