海峡药学
海峽藥學
해협약학
STRAIT PHARMACEUTICAL JOURNAL
2014年
8期
13-16
,共4页
郑自通%庹勤慧%姚旭%阳巍%郑兴%廖端芳
鄭自通%庹勤慧%姚旭%暘巍%鄭興%廖耑芳
정자통%탁근혜%요욱%양외%정흥%료단방
烟酸%姜黄素%联合用药%降脂%炎症因子
煙痠%薑黃素%聯閤用藥%降脂%炎癥因子
연산%강황소%연합용약%강지%염증인자
Niacin%Curcumin%Combined-therapy%Hypolipidemic%Inflammatory factors
目的：探讨烟酸联合姜黄素对高脂血症大鼠的降脂作用及肝脏TNF-α与IL-6表达的影响。方法50只SD大鼠随机分为溶剂对照组、高脂模型组、烟酸组〔100mg/（kg· d）〕、姜黄素组〔200mg/（kg· d）〕、联合用药组〔姜黄素200mg/（kg· d）＋烟酸100mg/（kg· d）〕。8周后检测大鼠血脂，处死，取其肝脏，HE染色，免疫组化检测肝脏TNF-α与IL-6的表达情况。结果与对照组相比，高脂模型组的TC、LDL均明显升高（P＜0.05），肝脏TNF-α与IL-6表达明显增高。与高脂模型组相比，烟酸组能降低TG、LDL含量（P＜0.05），姜黄素组与联合用药组均能显著降低TC、TG、LDL含量（P＜0.05），肝脏TNF-α与IL-6表达明显降低。结论烟酸与姜黄素联合用药可增强降脂作用，且较两者单独用药效果更佳；联合用药能够明显降低肝脏TNF-α与IL-6的表达。
目的：探討煙痠聯閤薑黃素對高脂血癥大鼠的降脂作用及肝髒TNF-α與IL-6錶達的影響。方法50隻SD大鼠隨機分為溶劑對照組、高脂模型組、煙痠組〔100mg/（kg· d）〕、薑黃素組〔200mg/（kg· d）〕、聯閤用藥組〔薑黃素200mg/（kg· d）＋煙痠100mg/（kg· d）〕。8週後檢測大鼠血脂，處死，取其肝髒，HE染色，免疫組化檢測肝髒TNF-α與IL-6的錶達情況。結果與對照組相比，高脂模型組的TC、LDL均明顯升高（P＜0.05），肝髒TNF-α與IL-6錶達明顯增高。與高脂模型組相比，煙痠組能降低TG、LDL含量（P＜0.05），薑黃素組與聯閤用藥組均能顯著降低TC、TG、LDL含量（P＜0.05），肝髒TNF-α與IL-6錶達明顯降低。結論煙痠與薑黃素聯閤用藥可增彊降脂作用，且較兩者單獨用藥效果更佳；聯閤用藥能夠明顯降低肝髒TNF-α與IL-6的錶達。
목적：탐토연산연합강황소대고지혈증대서적강지작용급간장TNF-α여IL-6표체적영향。방법50지SD대서수궤분위용제대조조、고지모형조、연산조〔100mg/（kg· d）〕、강황소조〔200mg/（kg· d）〕、연합용약조〔강황소200mg/（kg· d）＋연산100mg/（kg· d）〕。8주후검측대서혈지，처사，취기간장，HE염색，면역조화검측간장TNF-α여IL-6적표체정황。결과여대조조상비，고지모형조적TC、LDL균명현승고（P＜0.05），간장TNF-α여IL-6표체명현증고。여고지모형조상비，연산조능강저TG、LDL함량（P＜0.05），강황소조여연합용약조균능현저강저TC、TG、LDL함량（P＜0.05），간장TNF-α여IL-6표체명현강저。결론연산여강황소연합용약가증강강지작용，차교량자단독용약효과경가；연합용약능구명현강저간장TNF-α여IL-6적표체。
OBJECTIVE To study the effect of niacin combined with curcumin on blood lipids and inflammatory factors expression in hyperlipidemic rats.METHODS Fifty SD rats were randomly divided into normal control group,model group,niacin group〔niacin 100mg/(kg· d)〕,curcumin group 〔curcumin 100mg/(kg· d)〕and com-bination therapy group 〔Niacin 100mg/(kg· d) +curcumin 200mg/(kg· d)〕.Detection of serum lipids after 8 weeks.All the rats were killed and the liver samples were taken ,expression of TNF-αand IL-6 in liver were detected by immunohistochemical after hematoxylin-eosin staining.RESULTS Compared to the normal control group , the content of TC and LDL in the model group was significantly higher ( P<0.05 ).TNF-αand IL-6 expression in the liver was significantly increased.Compared with the model group ,niacin group can obviously decrease the content of TG and LDL ( P<0.05 ).Curcumin group and combination therapy group can both lower the content of TC ,TG and LDL significantly ( P<0.05 ).TNF-αand IL-6 expression in the liver was significantly decreased.CONCLUSION The hypolipidemic effects can be improved by combining niacin and curcumin ,better than using these two drugs individually.Combined therapy can decrease hepatic TNF-αand IL-6 expression at significant level.
