中华老年心脑血管病杂志
中華老年心腦血管病雜誌
중화노년심뇌혈관병잡지
CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
2014年
9期
916-919
,共4页
王超权%徐雅%任品芳%王翔
王超權%徐雅%任品芳%王翔
왕초권%서아%임품방%왕상
心肌梗死%降钙素原%C反应蛋白质%炎症%预后
心肌梗死%降鈣素原%C反應蛋白質%炎癥%預後
심기경사%강개소원%C반응단백질%염증%예후
myocardial infarction%procalcitonin%C-reactive protein%inflammation%prognosis
目的：探讨老年急性心肌梗死（AMI）患者血清降钙素原（PCT）水平变化与近期临床预后的关系。方法选择97例老年AMI患者作为病例组，同期体检者80例作为对照组。测定血清PCT和高敏C反应蛋白（hs-CRP）水平，AMI患者根据血清PCT水平分为正常组（＜0．5μg/L）23例、轻度升高组（0．5～1．9μg/L）41例和明显升高组（≥2．0μg/L）33例。随访患者30 d心源性死亡和主要心血管不良事件（MACE）发生率。结果病例组患者血清PCT、hs-CRP水平明显高于对照组，差异有统计学意义[（3．14±1．59）μg/L vs （0．15±0．04）μg/L ，（95．21±20.17）mg/L vs （11．32±9．30）mg/L ，P＜0．01]。与正常组和轻度升高组比较，明显升高组心源性死亡和MACE发生率显著增加（0％和7．3％ vs 24．2％，13．0％和22．0％ vs 45．5％，P＜0．05）。血清PCT与hs-CRP呈正相关（r＝0．4721，P＝0．032）。血清PCT可预测老年AMI患者30 d心源性死亡和MACE发生率（OR＝5．011，OR＝4．312， P＜0．01）。结论老年AMI患者血清PCT水平升高，对预测近期心源性死亡和MACE有一定参考价值。
目的：探討老年急性心肌梗死（AMI）患者血清降鈣素原（PCT）水平變化與近期臨床預後的關繫。方法選擇97例老年AMI患者作為病例組，同期體檢者80例作為對照組。測定血清PCT和高敏C反應蛋白（hs-CRP）水平，AMI患者根據血清PCT水平分為正常組（＜0．5μg/L）23例、輕度升高組（0．5～1．9μg/L）41例和明顯升高組（≥2．0μg/L）33例。隨訪患者30 d心源性死亡和主要心血管不良事件（MACE）髮生率。結果病例組患者血清PCT、hs-CRP水平明顯高于對照組，差異有統計學意義[（3．14±1．59）μg/L vs （0．15±0．04）μg/L ，（95．21±20.17）mg/L vs （11．32±9．30）mg/L ，P＜0．01]。與正常組和輕度升高組比較，明顯升高組心源性死亡和MACE髮生率顯著增加（0％和7．3％ vs 24．2％，13．0％和22．0％ vs 45．5％，P＜0．05）。血清PCT與hs-CRP呈正相關（r＝0．4721，P＝0．032）。血清PCT可預測老年AMI患者30 d心源性死亡和MACE髮生率（OR＝5．011，OR＝4．312， P＜0．01）。結論老年AMI患者血清PCT水平升高，對預測近期心源性死亡和MACE有一定參攷價值。
목적：탐토노년급성심기경사（AMI）환자혈청강개소원（PCT）수평변화여근기림상예후적관계。방법선택97례노년AMI환자작위병례조，동기체검자80례작위대조조。측정혈청PCT화고민C반응단백（hs-CRP）수평，AMI환자근거혈청PCT수평분위정상조（＜0．5μg/L）23례、경도승고조（0．5～1．9μg/L）41례화명현승고조（≥2．0μg/L）33례。수방환자30 d심원성사망화주요심혈관불량사건（MACE）발생솔。결과병례조환자혈청PCT、hs-CRP수평명현고우대조조，차이유통계학의의[（3．14±1．59）μg/L vs （0．15±0．04）μg/L ，（95．21±20.17）mg/L vs （11．32±9．30）mg/L ，P＜0．01]。여정상조화경도승고조비교，명현승고조심원성사망화MACE발생솔현저증가（0％화7．3％ vs 24．2％，13．0％화22．0％ vs 45．5％，P＜0．05）。혈청PCT여hs-CRP정정상관（r＝0．4721，P＝0．032）。혈청PCT가예측노년AMI환자30 d심원성사망화MACE발생솔（OR＝5．011，OR＝4．312， P＜0．01）。결론노년AMI환자혈청PCT수평승고，대예측근기심원성사망화MACE유일정삼고개치。
Objective To study the relation between serum procalcitonin (PCT ) level and short-term clinical outcome in elderly patients with acute myocardial infarction (AMI) .Methods Nine-ty-seven elderly AMI patients served as an AMI group and 80 subjects undergoing physical exami-nation served as a control group in this study .Their serum PCT and hs-CRP levels were meas-ured .The patients were further divided into normal group with its serum PCT <0 .5 μg/L (n=23) ,mild group with its serum PCT 0 .5 -1 .9 μg/L (n=41) ,and severe group with its serum PCT ≥2 .0 μg/L(n=33) .The mortality and incidence of major adverse cardiac events (MACE)on day 30 of follow-up were recorded .Results The serum PCT and hs-CRP levels were significantly higher in AMI group than in control group (3 .14 ± 1 .59μg/L vs 0 .15 ± 0 .04μg/L ,95 .21 ± 20 .17 mg/L vs 11 .32 ± 9 .30 mg/L ,P<0 .01) .The mortality and incidence of MACE were significantly higher in normal group than in mild group (0% and 7 .3% vs 24.2% ,13 .0% and 22 .0% vs 45.5% ,P<0 .05) .The serum PCT level was positively related with the serum hs-CRP level (r=0 .4721 ,P=0 .032) .The serum PCT level could predict the mortality and incidence of MACE on day 30 of follow-up (OR=5 .011 ,4 .312 ,P<0 .01) .Conclusion The serum PCT level is higher in elderly AMI patients and can predict their short-term(within 30 days)outcome and MACE .
