中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2014年
9期
1205-1208
,共4页
高同型半胱氨酸血症%心脑血管疾病%神经系统疾病%糖尿病并发症%机制%研究进展
高同型半胱氨痠血癥%心腦血管疾病%神經繫統疾病%糖尿病併髮癥%機製%研究進展
고동형반광안산혈증%심뇌혈관질병%신경계통질병%당뇨병병발증%궤제%연구진전
hyperhomocysteinemia%cardiac-cerebralvascular diseases%neurological diseases%diabetic complications%patho-genesis%progress
同型半胱氨酸( homocysteine, Hcy)是多种疾病的独立危险因素,与心脑血管疾病、神经系统疾病、糖尿病及其并发症等密切相关。高Hcy可以明显增加脑卒中患者心脑血管事件再发风险和脑卒中复发风险,升高全因死亡率；Hcy超过14μmol·L-1,老年痴呆的危险性增加1.8倍；糖尿病患者血浆Hcy水平每升高5μmol·L-1,未来5年内死亡率增加5倍。高Hcy可通过氧化应激、损伤血管内皮细胞、刺激血管平滑肌细胞增殖、影响凝血、脂质代谢功能,改变基因组甲基化水平等多种机制诱导疾病的发生。
同型半胱氨痠( homocysteine, Hcy)是多種疾病的獨立危險因素,與心腦血管疾病、神經繫統疾病、糖尿病及其併髮癥等密切相關。高Hcy可以明顯增加腦卒中患者心腦血管事件再髮風險和腦卒中複髮風險,升高全因死亡率；Hcy超過14μmol·L-1,老年癡呆的危險性增加1.8倍；糖尿病患者血漿Hcy水平每升高5μmol·L-1,未來5年內死亡率增加5倍。高Hcy可通過氧化應激、損傷血管內皮細胞、刺激血管平滑肌細胞增殖、影響凝血、脂質代謝功能,改變基因組甲基化水平等多種機製誘導疾病的髮生。
동형반광안산( homocysteine, Hcy)시다충질병적독립위험인소,여심뇌혈관질병、신경계통질병、당뇨병급기병발증등밀절상관。고Hcy가이명현증가뇌졸중환자심뇌혈관사건재발풍험화뇌졸중복발풍험,승고전인사망솔；Hcy초과14μmol·L-1,노년치태적위험성증가1.8배；당뇨병환자혈장Hcy수평매승고5μmol·L-1,미래5년내사망솔증가5배。고Hcy가통과양화응격、손상혈관내피세포、자격혈관평활기세포증식、영향응혈、지질대사공능,개변기인조갑기화수평등다충궤제유도질병적발생。
Homocysteine ( Hcy) is an independent risk factor for a variety of diseases and closely related to cardiac-cerebralvascu-lar diseases, neurological diseases, diabetes and diabetic com-plications. High homocysteine levels can significantly increase the recurrence risks of cardiac-cerebralvascular events and stroke in patients with stroke, leading to high all-cause mortality. The risk of Alzheimer’s disease is increased by 1. 8 fold when the concentration of Hcy is over 14 μmol·L-1 . For each 5 μmol· L-1 increase in plasma Hcy in diabetes patients, the mortality rate increases by 5 fold in the next five years. High Hcy triggers the pathogenesis of diseases via multiple mechanisms including oxidative stress, lesions of vascular endothelial cells, prolifera-tion of vascular smooth muscle cells, dysfunction of coagulation and lipid metabolism and genomic hypomethylation etc.
