CAJ | 학술논문

睡眠障碍系指睡眠-觉醒过程中表现出来的各种功能障碍,包括各种原因导致的失眠、过度嗜睡、睡眠呼吸障碍以及睡眠行为异常。睡眠障碍影响脑内β淀粉样蛋白( amy-loid beta protein, Aβ)的正常代谢,加速Aβ沉积。阿尔采末病(Alzheimer's disease, AD)患者常伴有睡眠障碍,AD患者的睡眠障碍会随着AD病情的发展而加重,对认知损伤、功能衰退都有一定影响。睡眠障碍与AD相互作用,形成正反馈环,严重危害机体健康。该文结合近来研究结果,对目前睡眠障碍与AD的相关研究及AD睡眠障碍药物治疗现状进行综述。
수면장애계지수면-각성과정중표현출래적각충공능장애,포괄각충원인도치적실면、과도기수、수면호흡장애이급수면행위이상。수면장애영향뇌내β정분양단백( amy-loid beta protein, Aβ)적정상대사,가속Aβ침적。아이채말병(Alzheimer's disease, AD)환자상반유수면장애,AD환자적수면장애회수착AD병정적발전이가중,대인지손상、공능쇠퇴도유일정영향。수면장애여AD상호작용,형성정반궤배,엄중위해궤체건강。해문결합근래연구결과,대목전수면장애여AD적상관연구급AD수면장애약물치료현상진행종술。
Sleep disorders are common diseases with various dys-function during sleep-wake process, including difficulty falling or staying asleep, falling asleep at inappropriate times, excessive total sleep time, or abnormal behaviors associated with sleep. Sleep disorders can lead to the deposition of amyloid beta protein ( Aβ) by affecting the normal metabolism of amyloid beta protein in the brain. Patients with Alzheimer’s disease ( AD) often suffer from sleep disorders, and its pathology always results in more se-vere sleep disorders, which leads to a risk of cognitive impair-ment and hypofunction. Sleep disorders could interact closely with AD, forming a positive feedback loop, which causes serious damage to the body health. This review summarized the current research about sleep disorder in the onset of AD and the current status of medication.