CAJ | 학술논문

示了良好的抗肿瘤效果。其发挥抗肿瘤作用机制涉及促凋亡、防扩散、抑制血管生成、抗转移和抑制P-糖蛋白，还有一些组织器官特异性通路。本文主要介绍PGG对多种肿瘤细胞的作用并讨论其在抗肿瘤领域的应用前景。
시료량호적항종류효과。기발휘항종류작용궤제섭급촉조망、방확산、억제혈관생성、항전이화억제P-당단백，환유일사조직기관특이성통로。본문주요개소PGG대다충종류세포적작용병토론기재항종류영역적응용전경。
1,2,3,4,6-penta-O-galloyl-β-D-glucose(PGG)is a naturally occurring polyphenolic compound and exhibits multiple biological activities,such as anti-oxidant,anti-inflammatory,cell protection,and anti-diabetes. PGG has shown to have in vitro inhibitory effects on the growth and/or invasion of some cancer.Mechanistic studies u-sing cell culture indicated the involvement of pro-apoptosis,anti-proliferation,anti-angiogenesis,anti-metast-asis and inhibition of P-glycoprotein,as well as other organ-specific pathways.In this review,we show the inhibito-ry effects PGG have on cancers,and discuss its application prospect in anti-tumor.