CAJ | 학술논문

微小核糖核酸（microRNA），简称miRNA，参与着生命活动的病理生理过程，在人体血清、血浆等体液中存在丰富而稳定的循环miRNA。简述了循环miRNA与病毒性肝炎、肝纤维化、肝硬化、肝癌、药物性肝炎等肝胆疾病或疾病不同阶段的表达谱存在明显差异性，其中一些循环miRNA可作为相关疾病早期诊断、病情进展和预后评估的新型无创性生物标志。本文就循环miRNA在肝胆疾病诊断研究中的最新进展作一综述。
미소핵당핵산（microRNA），간칭miRNA，삼여착생명활동적병리생리과정，재인체혈청、혈장등체액중존재봉부이은정적순배miRNA。간술료순배miRNA여병독성간염、간섬유화、간경화、간암、약물성간염등간담질병혹질병불동계단적표체보존재명현차이성，기중일사순배miRNA가작위상관질병조기진단、병정진전화예후평고적신형무창성생물표지。본문취순배miRNA재간담질병진단연구중적최신진전작일종술。
MicroRNAs (miRNAs)are involved in the pathological and physiological process of life activities,and some of them exist stably and abundantly in serum,plasma,and other body fluids.Previous studies have indicated that there are significant differences in the expres-sion patterns of circulating miRNAs between patients with viral hepatitis,liver fibrosis,liver cirrhosis,hepatocellular carcinoma,drug-in-duced hepatitis,and other hepatobiliary diseases at different disease stages.Among these circulating miRNAs,some can act as novel nonin-vasive biomarkers for the early diagnosis,disease progression,and prognostic evaluation of related diseases.The latest research advances in circulating miRNAs for the diagnosis of hepatobiliary diseases are reviewed.