临床肝胆病杂志
臨床肝膽病雜誌
림상간담병잡지
CHINESE JOURNAL OF CLINICAL HEPATOLOGY
2014年
9期
939-943
,共5页
纪柏(综述)%刘亚辉(审校)
紀柏(綜述)%劉亞輝(審校)
기백(종술)%류아휘(심교)
肝肿瘤%肝硬化%髓样抑制细胞%综述
肝腫瘤%肝硬化%髓樣抑製細胞%綜述
간종류%간경화%수양억제세포%종술
liver neoplasms%liver cirrhosis%myeloid derived suppressor cells%review
总结了髓样抑制细胞(MDSC)在促进炎症发生和肿瘤细胞的免疫逃逸中发挥的作用,以及促进肿瘤发生发展的作用机制。可为以后探讨肝纤维化和肝癌发病的免疫学机制提供一条新的思路,也将有利于未来寻找肝纤维化和肝癌治疗的有效靶点。
總結瞭髓樣抑製細胞(MDSC)在促進炎癥髮生和腫瘤細胞的免疫逃逸中髮揮的作用,以及促進腫瘤髮生髮展的作用機製。可為以後探討肝纖維化和肝癌髮病的免疫學機製提供一條新的思路,也將有利于未來尋找肝纖維化和肝癌治療的有效靶點。
총결료수양억제세포(MDSC)재촉진염증발생화종류세포적면역도일중발휘적작용,이급촉진종류발생발전적작용궤제。가위이후탐토간섬유화화간암발병적면역학궤제제공일조신적사로,야장유리우미래심조간섬유화화간암치료적유효파점。
The role of myeloid-derived suppressor cells (MDSCs)in promoting inflammatory response and immune escape of tumor cells and the mechanism by which MDSCs promote the development and progression of tumors are reviewed.This could provide a new way for the investigation of immunological mechanism of liver fibrosis and liver cancer.Besides,MDSCs may be an effective therapeutic target for liver cirrhosis and liver cancer.