CAJ | 학술논문

机体与病毒相互作用维持稳态是一种自然属性。免疫系统一方面需要活化免疫应答作用，杀灭或清除病毒；另一方面要调控免疫应答不要过度，维持免疫系统的稳定状态。持续性肝炎病毒感染（如HBV、HCV）的原因是病毒分子成分损害机体免疫系统并发生变异逃逸免疫清除。机体与病毒长期共存是多种免疫细胞和分子参与的过程，是机体在抗病毒免疫应答过程中维持自身稳态的结果。对持续肝炎病毒感染过程中机体维持相对稳定状态的细胞与分子机制作一综述。
궤체여병독상호작용유지은태시일충자연속성。면역계통일방면수요활화면역응답작용，살멸혹청제병독；령일방면요조공면역응답불요과도，유지면역계통적은정상태。지속성간염병독감염（여HBV、HCV）적원인시병독분자성분손해궤체면역계통병발생변이도일면역청제。궤체여병독장기공존시다충면역세포화분자삼여적과정，시궤체재항병독면역응답과정중유지자신은태적결과。대지속간염병독감염과정중궤체유지상대은정상태적세포여분자궤제작일종술。
Homeostasis between the host and viruses is naturally maintained.On the one hand,the immune system activates the immune re-sponse to kill or eliminate viruses;on the other hand,the immune system controls the immune response to maintain immune homeostasis. The cause of persistent infections with hepatitis viruses such as HBV and HCV is that viral molecules damage the immune system of the host and their variants escape immune clearance.Long-term coexistence of the host and viruses is the process involving various immune cells and molecules and is the result of homeostasis maintenance in antiviral immune response.The immune homeostasis maintained during persis-tent infections with hepatitis viruses is analyzed by the cellular and molecular mechanisms.