CAJ | 학술논문

肝脏是一个重要的免疫器官，具有独特的免疫微环境，参与全身固有免疫应答和适应性免疫反应。肝脏通过肝-肠轴与系统免疫密切相连，又是免疫损伤的靶器官；肝脏在抗嗜肝病毒免疫中发挥着重要作用，但导致病毒感染慢性化机制尚不完全清楚。肝病细胞治疗包括以细胞功能替代为主的肝（干）细胞输入治疗；以抗病毒抗肿瘤为主的免疫细胞治疗和对遗传性肝病进行的以细胞为载体的基因治疗。间充质干细胞的多向分化潜能和免疫调节特性成为肝病细胞治疗的热点，体外高效扩增技术使自然杀伤细胞治疗肝癌成为可能。
간장시일개중요적면역기관，구유독특적면역미배경，삼여전신고유면역응답화괄응성면역반응。간장통과간-장축여계통면역밀절상련，우시면역손상적파기관；간장재항기간병독면역중발휘착중요작용，단도치병독감염만성화궤제상불완전청초。간병세포치료포괄이세포공능체대위주적간（간）세포수입치료；이항병독항종류위주적면역세포치료화대유전성간병진행적이세포위재체적기인치료。간충질간세포적다향분화잠능화면역조절특성성위간병세포치료적열점，체외고효확증기술사자연살상세포치료간암성위가능。
As an important immune organ,the liver has a unique immune microenvironment,and is one of the important places for innate immunity and adaptive immunity.The liver is closely connected with the immune system through the gut-liver axis and is also the target or-gan of immune injury.However,the defensive role of the liver for Hepadnaviridae remains unclear.Cell therapy for liver diseases includes input of liver cells or stem cells for functional replacement,therapy by immune cells for antiviral and antitumor purposes,and genetic therapy for hereditary hepatopathy with cells as the carrier.The features of mesenchymal stem cells,multi-directional differentiation potential and immunomodulatory property,become the hot spots of cell therapy for liver diseases,and efficient in vitro amplification of cells makes it possi-ble for the use of NK cells in the treatment of hepatocellular carcinoma.