CAJ | 학술논문

目的：探讨以双歧杆菌为主的益生菌预防抗生素相关性肠道菌群失调的作用。方法：将200例需要长时间应用抗生素的患者随机分为治疗组和对照组，治疗组在使用抗生素治疗的同时加用双歧杆菌三联活菌胶囊（培菲康）630 mg，每天3次，口服，分别观察两组患者肠道菌群失调发生率。结果：肠道菌群失调发生率治疗组为9%，对照组为37%，两组比较差异有统计学意义（ P﹤0.01），肠道菌群失调发生与基础疾病和年龄有相关性。结论：益生菌可以有效预防抗生素相关性肠道菌群失调的发生，使用抗生素患者应该同时服用益生菌药物。
목적：탐토이쌍기간균위주적익생균예방항생소상관성장도균군실조적작용。방법：장200례수요장시간응용항생소적환자수궤분위치료조화대조조，치료조재사용항생소치료적동시가용쌍기간균삼련활균효낭（배비강）630 mg，매천3차，구복，분별관찰량조환자장도균군실조발생솔。결과：장도균군실조발생솔치료조위9%，대조조위37%，량조비교차이유통계학의의（ P﹤0.01），장도균군실조발생여기출질병화년령유상관성。결론：익생균가이유효예방항생소상관성장도균군실조적발생，사용항생소환자응해동시복용익생균약물。
Objective:To investigate the effect of probiotics mainly with bifidobacterium in the prevention of antibiotic-associated intestinal dysbacteriosis. Methods:Tow hundreds patients who needed a long time use of antibiotics were randomly divided into treatment group and control group. The treatment group was treated with oral bifidobacterim capsules,2 capsules, 3 times daily. The incidence of intestinal dysbacteriosis was observed in the two groups of patients. Results:The incidence of in-testinal dysbacteriosis in treatment group and control group patients was 9% and 37%. The difference between the two groups was statistically significant(P﹤0. 01). The incidence of intestinal dysbacteriosis was related to the primary diseases and age. Conclusion:Probiotics can be effective in preventing incidence of antibiotic-associated intestinal dysbacteriosis. The use of an-tibiotics in patients should also take probiotics drug at the same time.