CAJ | 학술논문

目的：对4-氯-3-甲氧基-2-甲基吡啶制备工艺进行优化。方法选择甲苯作为反应溶剂，氧氯化磷稍过量，反应毕直接用氢氧化钠中和，分层萃取，蒸出溶剂即得产品。结果通过对4-氯-3-甲氧基-2-甲基吡啶制备工艺的优化，减少了氧氯化磷的用量，缩短反应时间至2 h，降低反应 pH 值至接近中性。结论本工艺有效地减少了对环境的污染，降低了生产成本，有利于提高经济效益。
목적：대4-록-3-갑양기-2-갑기필정제비공예진행우화。방법선택갑분작위반응용제，양록화린초과량，반응필직접용경양화납중화，분층췌취，증출용제즉득산품。결과통과대4-록-3-갑양기-2-갑기필정제비공예적우화，감소료양록화린적용량，축단반응시간지2 h，강저반응 pH 치지접근중성。결론본공예유효지감소료대배경적오염，강저료생산성본，유리우제고경제효익。
Objective To optimize the preparation technology of 4 - Chloro - 3 - Methoxy - 2 - Methylpyridine N -Oxide's. Methods We chose toluene as solvent,oxygen phosphorus chloride was a bit too much,ended the reaction with sodium hydroxide directly,then extracted hierarchically,evaporated the solvent for the production. Results Through the op-timization of 4 - Chloro - 3 - Methoxy - 2 - Methylpyridine N - Oxide's preparation technology,we reduced the amount of phosphorus oxychloride,shortened the reaction time to 2 h,cuted down the reaction pH close to neutral. Conclusion The preparation technology reduced the pollution to the environment and the production cost effectively,and improves the eco-nomic benefits.