药学研究
藥學研究
약학연구
JOURNAL OF PHARMACEUTICAL RESEARCH
2014年
9期
550-551
,共2页
张涛%孔令金%丁珊珊%刘新泳
張濤%孔令金%丁珊珊%劉新泳
장도%공령금%정산산%류신영
阿哌沙班%合成%抗凝血
阿哌沙班%閤成%抗凝血
아고사반%합성%항응혈
Apixaban%Synthesis%Anticoagulation
目的：合成阿哌沙班。方法以对甲氧基苯胺为原料经胺基取代、环加成、催化以及胺化得到产品阿哌沙班。结果用廉价原料合成了阿哌沙班，总收率10%。结论该工艺适合工业化生产。
目的：閤成阿哌沙班。方法以對甲氧基苯胺為原料經胺基取代、環加成、催化以及胺化得到產品阿哌沙班。結果用廉價原料閤成瞭阿哌沙班，總收率10%。結論該工藝適閤工業化生產。
목적：합성아고사반。방법이대갑양기분알위원료경알기취대、배가성、최화이급알화득도산품아고사반。결과용렴개원료합성료아고사반，총수솔10%。결론해공예괄합공업화생산。
Objective To synthesize of apixaban. Methods Apixaban was synthesized from p - anisidine by substitu-tion,cycloaddition,reduction and amination. Results Apixaban was synthesized with inexpensive and readily available cat-alyst and the total yield of the target compound was 10% . Conclusion The process was suitable for industrial production.
