蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2014年
9期
1277-1279
,共3页
关节炎,类风湿性%抗环瓜氨酸肽抗体%类风湿因子
關節炎,類風濕性%抗環瓜氨痠肽抗體%類風濕因子
관절염,류풍습성%항배과안산태항체%류풍습인자
arthritis,rheumatoid%anti-cyclic citrullinated peptide antibody%rheumatoid factor
目的：探讨抗环瓜氨酸肽抗体(抗CCP)与类风湿因子( RF)联合检测在类风湿关节炎( RA)中的诊断价值。方法：收集RA患者40例,非RA风湿病患者40例,体检健康人(健康对照组)40名,测定其抗CCP抗体水平和RF值,比较抗CCP抗体和RF对RA诊断的敏感度和特异度。结果：RA组患者血清抗CCP抗体和RF值均显著高于非RA风湿病组和健康对照组( P<0.01)。抗CCP抗体,RF单独测定时特异度分别为97.50%和83.75%,灵敏度分别为65.0%和67.5%,2者特异度差异有统计学意义(P<0.01),灵敏度差异无统计学意义(P>0.05)；联合检测抗CCP抗体和RF特异度和灵敏度分别为98.75%和82.50%。结论：抗CCP抗体对RA具有较高的诊断价值,抗CCP抗体和RF联合检测可提高检测的特异度。
目的：探討抗環瓜氨痠肽抗體(抗CCP)與類風濕因子( RF)聯閤檢測在類風濕關節炎( RA)中的診斷價值。方法：收集RA患者40例,非RA風濕病患者40例,體檢健康人(健康對照組)40名,測定其抗CCP抗體水平和RF值,比較抗CCP抗體和RF對RA診斷的敏感度和特異度。結果：RA組患者血清抗CCP抗體和RF值均顯著高于非RA風濕病組和健康對照組( P<0.01)。抗CCP抗體,RF單獨測定時特異度分彆為97.50%和83.75%,靈敏度分彆為65.0%和67.5%,2者特異度差異有統計學意義(P<0.01),靈敏度差異無統計學意義(P>0.05)；聯閤檢測抗CCP抗體和RF特異度和靈敏度分彆為98.75%和82.50%。結論：抗CCP抗體對RA具有較高的診斷價值,抗CCP抗體和RF聯閤檢測可提高檢測的特異度。
목적：탐토항배과안산태항체(항CCP)여류풍습인자( RF)연합검측재류풍습관절염( RA)중적진단개치。방법：수집RA환자40례,비RA풍습병환자40례,체검건강인(건강대조조)40명,측정기항CCP항체수평화RF치,비교항CCP항체화RF대RA진단적민감도화특이도。결과：RA조환자혈청항CCP항체화RF치균현저고우비RA풍습병조화건강대조조( P<0.01)。항CCP항체,RF단독측정시특이도분별위97.50%화83.75%,령민도분별위65.0%화67.5%,2자특이도차이유통계학의의(P<0.01),령민도차이무통계학의의(P>0.05)；연합검측항CCP항체화RF특이도화령민도분별위98.75%화82.50%。결론：항CCP항체대RA구유교고적진단개치,항CCP항체화RF연합검측가제고검측적특이도。
Objective:To investigate the anti-CCP and rheumatoid factor( RF) in the diagnosis of rheumatoid arthritis( RA) patients. Methods:Forty cases of patients with RA and 40 cases of patients with other autoimmune diseases and 40 health people( control group) were selected. The concentration of anti-CCP was determined by electrochemical luminescence analysis and the concentration of RF was determined by chemical analysis,diagnostic sensitivity and specificity of anti-CCP antibodies and RF in RA were compared. Results:The anti-CCP content in the serum of RA patients was found distinctly higher than the control group and non-RA group(P<0. 01), control group and non-RA group showed no significant difference with the level of anti-CCP antibody(P>0. 05). The sensitivity of anti-CCP antibody and RF was 97. 50% and 83. 75%,there was significant difference between them(P<0. 01). The specificity of anti-CCP antibody and RF was 65. 0% and 67. 5%,there was no significant difference between them(P>0. 05). The specificity and sensitivity of combined detection of anti-CCP and RF were 98. 75% and 82. 50%. Conclusions:Detection of anti-CCP in Serum has a great value for diagnosis of RA and could be an ideal serological data for diagnosis of RA. Combined detection of anti-CCP antibody and RF could increase the diagnostic specificity and sensitivity.
