CAJ | 학술논문

目的：探讨原发性卵巢甲状腺肿类癌( POSC)的临床病理特征。方法：应用光镜、免疫组织化学、特殊染色技术对4例POSC进行临床病理分析。结果：患者临床表现为腹痛及盆腔肿块,无便秘、类癌综合征表现,其中2例以卵巢囊状肿块蒂扭转为首发症状。组织学上甲状腺肿与类癌相移行,部分类癌细胞排列成岛状或梁状,1例伴有交界性黏液性囊腺瘤成分,3例伴有成熟性畸胎瘤。免疫表型：类癌细胞神经细胞黏附分子、突触素、嗜铬素、神经元特异性烯醇化酶均阳性。结论：POSC是一种罕见的生殖细胞肿瘤,形态学上需要与卵巢粒层细胞瘤、Sertoli-Leydig细胞瘤等相鉴别,HE切片及免疫组织化学标记可以有效地帮助诊断。
목적：탐토원발성란소갑상선종유암( POSC)적림상병리특정。방법：응용광경、면역조직화학、특수염색기술대4례POSC진행림상병리분석。결과：환자림상표현위복통급분강종괴,무편비、유암종합정표현,기중2례이란소낭상종괴체뉴전위수발증상。조직학상갑상선종여유암상이행,부분유암세포배렬성도상혹량상,1례반유교계성점액성낭선류성분,3례반유성숙성기태류。면역표형：유암세포신경세포점부분자、돌촉소、기락소、신경원특이성희순화매균양성。결론：POSC시일충한견적생식세포종류,형태학상수요여란소립층세포류、Sertoli-Leydig세포류등상감별,HE절편급면역조직화학표기가이유효지방조진단。
Objective:To investigate the clinicopathological characteristics of primary ovarian strumal carcinoid(POSC). Methods:The clinicopathological characteristics of POSC in 4 cases were analyzed by light microscopy,immunohistochemistry and special stains. Results:The patients’ clinical manifestations were lower abdominal pain,and no constipation and carcinoid syndrome. Ovarian cystic masses torsion was the initia symptom in 2 cases. The goiter and carcinoid tissue were transition,part cancer cells arranged in island or beam. The borderline mucinous cystadenoma in 1 case and mature teraloma in 3 cases were found. The neural cell adhesion molecule of immune phenotype cancer cells,synaptophysin,chromogranin and neuron specific enolase were positive. Conclusions:POSC is a rare germ cell tumor,which should be differentiated from granulosa cell tumor and Sertoli-Leydig cell tumor. HE and immunohistochemical stain will contribute to the diagnosis.