CAJ | 학술논문

目的：分析急性有机磷农药中毒（ AOPP）致呼吸衰竭的相关临床因素，为制订有效的预防及干预措施提供科学依据。方法回顾分析94例重性AOPP患者临床资料，根据血气分析结果将患者分为呼吸衰竭组（41例）和非呼吸衰竭组（53例），观察患者的APACHEⅡ评分、胆碱酯酶、血糖、血清淀粉酶、肝肾功能及心肌酶谱等指标。结果胆碱酯酶水平呼吸衰竭组患者低于非呼吸衰竭组患者（P＜0．05）；APACHEⅡ评分、血清淀粉酶、肝肾功能及心肌酶谱等，呼吸衰竭组患者高于非呼吸衰竭组患者（P＜0．05）；Logistic回归分析显示APACHEⅡ评分、胆碱酯酶及血清淀粉酶与呼吸衰竭相关。结论 APACHEⅡ评分、胆碱酯酶及血清淀粉酶水平可作为AOPP引起呼吸衰竭的预测指标。
목적：분석급성유궤린농약중독（ AOPP）치호흡쇠갈적상관림상인소，위제정유효적예방급간예조시제공과학의거。방법회고분석94례중성AOPP환자림상자료，근거혈기분석결과장환자분위호흡쇠갈조（41례）화비호흡쇠갈조（53례），관찰환자적APACHEⅡ평분、담감지매、혈당、혈청정분매、간신공능급심기매보등지표。결과담감지매수평호흡쇠갈조환자저우비호흡쇠갈조환자（P＜0．05）；APACHEⅡ평분、혈청정분매、간신공능급심기매보등，호흡쇠갈조환자고우비호흡쇠갈조환자（P＜0．05）；Logistic회귀분석현시APACHEⅡ평분、담감지매급혈청정분매여호흡쇠갈상관。결론 APACHEⅡ평분、담감지매급혈청정분매수평가작위AOPP인기호흡쇠갈적예측지표。
Objective To investigate the correlated clinical factors of respiratory failure induced by acute organophosphorus pesticide poisoning ( AOPP) ,and to provide relevant data for prevention and intervention of respiratory failure .Methods This retrospective study in-cluded 94 patients with severe AOPP ,and all patients were divided into respiratory failure group ( n=41 ) and non-respiratory failure group (n=53) according to arterial blood gas analysis .We observed APACHEⅡscores,cholinesterase,blood glucose,serum amylase,hepatic func-tion,renal function and myocardial enzyme between the two groups .Results Cholinesterase level in the respiratory failure group was lower than that in non-respiratory failure group (P<0.05);APACHEⅡ scores,serum amylase,hepatic function,renal function and myocardial enzyme in the respiratory failure group were higher than those of non-respiratory failure group (P<0.05).Spearman correlation analysis and Logistic regression analyses showed APACHEⅡscores,cholinesterase and serum amylase were related to respiratory failure ,and they had sig-nificant predictive effects on respiratory failure .Conclusions The APACHEⅡscores,cholinesterase and serum amylase can be used for the prediction of respiratory failure induced by AOPP .