安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2014年
9期
1250-1252
,共3页
魏洁%吕星旺%杜兴龙%丁仁平
魏潔%呂星旺%杜興龍%丁仁平
위길%려성왕%두흥룡%정인평
食管肿瘤%放射疗法%大分割
食管腫瘤%放射療法%大分割
식관종류%방사요법%대분할
Esophageal neoplasmas%Radiotherapy%Hypofractionated
目的：探讨采用大分割适形放射治疗中晚期食管癌的近期疗效和毒副反应。方法将符合入组条件的49例中晚期食管癌患者行适形放射治疗，并随机分为两组。常规分割适形放疗组21例，每次剂量2．0 Gy，总剂量60．0～68．0 Gy；大分割适形放疗组28例，每次剂量2．4～3．0 Gy，总剂量60．0～62．5 Gy。两组均为每天照射1次，每周5次，以95％等剂量曲线作为剂量参考线。结果常规分割组和大分割组有效率分别为90．5％和92．9％；1年局控率分别为76．2％和82．1％；1年生存率分别为66．7％和71．4％；大分割组放射性食管炎及白细胞下降略高于常规分割组，差异无统计学意义（P＞0．05）。结论采用大分割三维适形放疗治疗中晚期食管癌是可行的。
目的：探討採用大分割適形放射治療中晚期食管癌的近期療效和毒副反應。方法將符閤入組條件的49例中晚期食管癌患者行適形放射治療，併隨機分為兩組。常規分割適形放療組21例，每次劑量2．0 Gy，總劑量60．0～68．0 Gy；大分割適形放療組28例，每次劑量2．4～3．0 Gy，總劑量60．0～62．5 Gy。兩組均為每天照射1次，每週5次，以95％等劑量麯線作為劑量參攷線。結果常規分割組和大分割組有效率分彆為90．5％和92．9％；1年跼控率分彆為76．2％和82．1％；1年生存率分彆為66．7％和71．4％；大分割組放射性食管炎及白細胞下降略高于常規分割組，差異無統計學意義（P＞0．05）。結論採用大分割三維適形放療治療中晚期食管癌是可行的。
목적：탐토채용대분할괄형방사치료중만기식관암적근기료효화독부반응。방법장부합입조조건적49례중만기식관암환자행괄형방사치료，병수궤분위량조。상규분할괄형방료조21례，매차제량2．0 Gy，총제량60．0～68．0 Gy；대분할괄형방료조28례，매차제량2．4～3．0 Gy，총제량60．0～62．5 Gy。량조균위매천조사1차，매주5차，이95％등제량곡선작위제량삼고선。결과상규분할조화대분할조유효솔분별위90．5％화92．9％；1년국공솔분별위76．2％화82．1％；1년생존솔분별위66．7％화71．4％；대분할조방사성식관염급백세포하강략고우상규분할조，차이무통계학의의（P＞0．05）。결론채용대분할삼유괄형방료치료중만기식관암시가행적。
Objective To explore the short-term curative effect and adverse reaction of hypofractionated conformal radiation therapy in treating advanced esophageal carcinoma .Methods Forty-nine patients with advanced esophageal carcinoma that would be treated with conformal radiotherapy were recruited in this study and were divided into two groups ,i.e.the conventional fractionation group which included 21 patients and were treated with the routine dose (2.0 Gy daily and the accumulated total dose was 60.0~68.0 Gy);the hypofractionated group which included 28 patients and were treated with hypofractionated conformal radiation therapy (2.4~3.0 Gy daily and the accumulated total dose was 60.0~62.5 Gy).Two groups were all treated once a day ,five times a week.The 95% of the isodose curve was taken as the reference dose curve.Results The response rates of the conventional group and the hypofractionated were 90.5%and 92.9%,respectively, 1-year local control rates were 76.2%and 82.1%,respectively,and 1-year survival rates were 66.7%and 71.4%,respectively.Besides,the rates of acute radiation-induced esophagitis and leucopenia in the hypofractionated group were a bit higher than those in the conventional group,but without statistical significance .Conclusions It is feasible to apply hypofractionated three-dimensional conformal radiotherapy in the treatment of advanced esophageal carcinoma .
