CAJ | 학술논문

采用剥离-共组装法制备了电中性疏水药物葫芦素( CA)插层类水滑石( HTlc)纳米杂化物.先用胆酸钠( Ch)包覆修饰葫芦素，再与剥离的HTlc薄片共组装，形成CA-Ch-HTlc纳米杂化物.采用小角X射线散射、傅里叶变换红外吸收光谱、透射和扫描电子显微镜、Zeta电位和元素分析等技术对样品进行了表征.所制备纳米杂化物的载药量达到7.06%，表明该方法可以实现电中性疏水药物在HTlc上的有效负载.依据胆酸离子和葫芦素尺寸及纳米杂化物通道高度推测，胆酸离子在HTlc层间为双层排列，其长轴几乎垂直于HTlc层板；葫芦素分子插入(或“溶入”)胆酸离子双层中. CA-Ch-HTlc纳米杂化物具有良好的药物缓释效果，其药物释放过程符合准二级动力学方程.
채용박리-공조장법제비료전중성소수약물호호소( CA)삽층류수활석( HTlc)납미잡화물.선용담산납( Ch)포복수식호호소，재여박리적HTlc박편공조장，형성CA-Ch-HTlc납미잡화물.채용소각X사선산사、부리협변환홍외흡수광보、투사화소묘전자현미경、Zeta전위화원소분석등기술대양품진행료표정.소제비납미잡화물적재약량체도7.06%，표명해방법가이실현전중성소수약물재HTlc상적유효부재.의거담산리자화호호소척촌급납미잡화물통도고도추측，담산리자재HTlc층간위쌍층배렬，기장축궤호수직우HTlc층판；호호소분자삽입(혹“용입”)담산리자쌍층중. CA-Ch-HTlc납미잡화물구유량호적약물완석효과，기약물석방과정부합준이급동역학방정.
A nanohybrid of cucurbitacin(CA), a charge-neutral and poorly water-soluble drug, intercalated hydrotalcite-like compounds( HTlc) was synthesized via a delamination-coassembling method. CA molecules were initially incorporated into the micelles of sodium cholate( Ch) , and the resulting negatively charged CA-loaded micelles and the positively charged delaminated HTlc nanosheets were then coassembled together into the CA-Ch-HTlc nanohybrid. The so-obtained nanohybrid was characterized by small angle X-ray scattering, Fourier transform infrared, transmission and scanning electron microscopy, zeta potential and elemental analyses. The results showed that the loading of CA in the nanohybrid was 7. 06%, indicating that this route could be used to achieve the effective intercalation of charge-neutral and poorly water-soluble drugs into the HTlc gallery. Based on the sizes of Ch and CA, and the gallery heights of the nanohybrid, a possible orienta-tion of Ch anions and CA molecules in the HTlc gallery was proposed. The Ch anions are arranged as a slightly tilted bilayer with their long axis approximately perpendicular to the brucite-like layer, and the CA molecules are encapsulated in the bilayer as a consequence of the hydrophobic interactions. The in vitro release of CA from the nanohybrid was examined, and the results showed that the nanohybrid had a good drug controlled release performance and its drug release process obeyed pseudo-second order kinetics model.