CAJ | 학술논문

目的：观察多西他赛联合铂类治疗晚期非小细胞肺癌（ NSCLC ）的临床疗效及不良反应。方法52例晚期NSCLC患者入组，16例为靶向治疗失败患者。多西他赛联合顺铂组（ DP组）31例，多西他赛75 mg/m2，静脉滴注l h，第1 d；顺铂75 mg/m2，静脉滴注，分3 d平均给药。多西他赛联合卡铂组（DC组）21例，多西他赛75 mg/m2，静脉滴注l h，第1 d；卡铂AUC＝5（300～400 mg/m2）计算，静脉滴注，第1 d。21～28 d为1个周期，化疗2个周期后评价疗效及不良反应。结果 DP组客观有效率（ORR）为38．7％，疾病控制率（DCR）为67．7％；DC组ORR为33．3％，DCR为61．9％，两组差异无统计学意义（P＞0．05）。16例靶向治疗失败患者ORR为12．5％，DCR为50．0％。不良反应主要为骨髓抑制、恶心、呕吐和脱发。结论多西他赛联合铂类治疗晚期NSCLC疗效确切，不良反应可耐受。
목적：관찰다서타새연합박류치료만기비소세포폐암（ NSCLC ）적림상료효급불량반응。방법52례만기NSCLC환자입조，16례위파향치료실패환자。다서타새연합순박조（ DP조）31례，다서타새75 mg/m2，정맥적주l h，제1 d；순박75 mg/m2，정맥적주，분3 d평균급약。다서타새연합잡박조（DC조）21례，다서타새75 mg/m2，정맥적주l h，제1 d；잡박AUC＝5（300～400 mg/m2）계산，정맥적주，제1 d。21～28 d위1개주기，화료2개주기후평개료효급불량반응。결과 DP조객관유효솔（ORR）위38．7％，질병공제솔（DCR）위67．7％；DC조ORR위33．3％，DCR위61．9％，량조차이무통계학의의（P＞0．05）。16례파향치료실패환자ORR위12．5％，DCR위50．0％。불량반응주요위골수억제、악심、구토화탈발。결론다서타새연합박류치료만기NSCLC료효학절，불량반응가내수。
Objective To observe the efficacy and toxicities of docetaxel combined with platinum in the treatment of patients with advanced non-small cell lung cancer ( NSCLC) .Methods Fifty-two patients with advanced NSCLC were enrolled into the study ,of which 16 patients were failure of target treatment .Thirty-one patients received docetaxel plus cisplatin ,docetaxel 75 mg/m2 ,1-hour intravenous infusion d 1;cisplatin 75 mg/m2 , intravenous infusion , d 1 ~3 individually .Twenty-one patients received docetaxel plus carbeplatin , docetaxel 75 mg/m2,1-hour intravenous infusion d1;carboplatin ACU=5(300~400 mg/m2),intravenous infusion d1,the chemotherapy was repeated ev-ery 21~28 days,and the efficacy and toxicities were assessed after two cycles .Results The response rate was 38.7%,and disease control rate was 67.7%in the DP group;the response rate was 33.3%,and disease control rate was 61.9%in the DC group.The difference between the two groups had no statistical significance .The response rate was 12.5%,and disease control rate was 50.0%in the 16 patients who were failure of target treatment.The major toxicities included myelesuppression ,nausea,vomiting and alopecia.Conclusion The combined chemo-therapy of docetaxel with platinum is effective in the treatment of patients with advanced non -small cell lung cancer ,and the toxicities are tol-erable.