CAJ | 학술논문

目的：探讨不同治疗方案治疗老年急性髓系白血病（ AML）患者的疗效和不良反应。方法60例初治老年AML患者分别接受化疗（标准剂量、减低剂量）及姑息治疗，分析各组患者临床疗效、生存期和不良反应情况。结果32例化疗患者有效率（RR）为62．5％，完全缓解率（CRR）为31．25％，姑息治疗组无一例患者获得完全缓解，1例获得部分缓解，RR为3．57％，两组RR差异有统计学意义（P＜0．05）。标准剂量化疗RR为61．11％，CRR为33．33％；减低剂量化疗RR为64．29％，CRR为28．57％，标准剂量化疗患者与减低剂量化疗患者RR差异无统计学意义（P＞0．05）。化疗组中位生存期高于姑息治疗组（P＜0．05），标准剂量化疗患者与减低剂量患者中位生存期差异无统计学意义（P＞0．05）。标准剂量化疗患者脏器功能障碍发生率高于减量剂量患者（P＜0．05）。结论诱导化疗可改善部分老年AML患者预后，延长生存期。
목적：탐토불동치료방안치료노년급성수계백혈병（ AML）환자적료효화불량반응。방법60례초치노년AML환자분별접수화료（표준제량、감저제량）급고식치료，분석각조환자림상료효、생존기화불량반응정황。결과32례화료환자유효솔（RR）위62．5％，완전완해솔（CRR）위31．25％，고식치료조무일례환자획득완전완해，1례획득부분완해，RR위3．57％，량조RR차이유통계학의의（P＜0．05）。표준제양화료RR위61．11％，CRR위33．33％；감저제양화료RR위64．29％，CRR위28．57％，표준제양화료환자여감저제양화료환자RR차이무통계학의의（P＞0．05）。화료조중위생존기고우고식치료조（P＜0．05），표준제양화료환자여감저제량환자중위생존기차이무통계학의의（P＞0．05）。표준제양화료환자장기공능장애발생솔고우감량제량환자（P＜0．05）。결론유도화료가개선부분노년AML환자예후，연장생존기。
Objective To explore the outcome of different therapeutic regimens in elderly patients with acute myeloid leukemia ( AML) .Methods The clinical data of 60 elderly AML patients who were treated with chemotherapy ( standard dose ,reduced dose ) and pal-liative treatment from July 2008 to July 2013 were analyzed retrospectively .The two groups were compared in therapeutic efficacy ,survival and complications.Results In the chemotherapy regime group of 32 cases,responding rate (RR) was 62.5%,and complete remission rate (CRR) was 31.25%.RR in the standard dose chemotherapy group was 61.11%,and CRR was 33.33%.In the reduced dose chemotherapy group RR was 64.29%,and CRR was 28.57%.One palliative care patients achieved PR ,and RR was 3.57%.The effective rate of chemo-therapy regime group was higher than that of palliative care group (P<0.05),but there was no difference between standard dose chmothera-pye group and reduced dose chemotherapy group (P>0.05).The median OS of chemotherapy group was longer than that of palliative treat-ment group (P<0.05).There was no difference between standard dose chemotherapy group and reduced dose chemotherapy group (P>0.05).The incidence rate of organ disfunction was higher in standard dose chemotherapy group than in reduced dose group (P<0.05).Con-clusions Induction chemotherapy can improve the survival time of partial elderly patients with AML and improve the prognosis .