CAJ | 학술논문

目的：观察乌司他丁对非小细胞肺癌( NSCLC)患者放疗后血清中TGF-β1、IL-6和TNF-α水平变化变化情况。方法120名NSCLC患者随机双盲分入实验组和对照组，实验组在放疗开始前3天及放疗中前7天接受乌司他丁治疗，同时对照组患者使用安慰剂治疗。在放疗开始前，放疗后第4、8、16、24周时检测患者血清中TGF-β1、IL-6和TNF-α水平。结果放疗后实验组患者血清中TGF-β1、IL-6和TNF-α水平明显低于对照组，特别是在前4周。结论乌司他丁能有效降低NSCLC患者放疗后血清中TGF-β1、IL-6和TNF-α水平。
목적：관찰오사타정대비소세포폐암( NSCLC)환자방료후혈청중TGF-β1、IL-6화TNF-α수평변화변화정황。방법120명NSCLC환자수궤쌍맹분입실험조화대조조，실험조재방료개시전3천급방료중전7천접수오사타정치료，동시대조조환자사용안위제치료。재방료개시전，방료후제4、8、16、24주시검측환자혈청중TGF-β1、IL-6화TNF-α수평。결과방료후실험조환자혈청중TGF-β1、IL-6화TNF-α수평명현저우대조조，특별시재전4주。결론오사타정능유효강저NSCLC환자방료후혈청중TGF-β1、IL-6화TNF-α수평。
Objective To investigate the effect of ulinastatin on TGF-β1, IL-6 and TNF-α in patients with NSCLC after radiation therapy. Methods 120 patients with NSCLC were randomly divided into two groups. The treatment group was treated with ulinastatin for 3 days prior to and for the first 7 days of radiotherapy, and the control group was treated with placebo for 10 days. TGF-β1, IL-6, and TNF-α levels were measured at baseline, 4w, 8w, 16w, and 24w. Results The expression of TGF-β1, TNF-α, and IL-6 in the trial group decreased significantly compared to the control group, especially up to 4 weeks after radiation therapy. Conclusion Ulinastatin can signifi-cantly decrease the levels of TGF-β1, IL-6, and TNF-α in NSCLC patients treated with radiotherapy.