CAJ | 학술논문

目的：观察并探讨胸腺肽在糖尿病合并结核病患者抗结核治疗中的作用。方法将入选的90例糖尿病合并肺结核患者随机分为观察组( n=47例)和对照组( n=43例),对照组在维持血糖基础上予常规抗结核治疗,观察组在此基础上加用胸腺肽注射液皮下注射,连用12周,对比两组治疗3个月后抗结核治疗效果。结果①治疗90 d后,观察组CD4+构成比及CD4+/CD8+比值明显高于对照组水平这P<0.05,而CD8+构成比(23.3±5.7)%显著低于对照组。②两组血糖控制平稳,观察组与治疗组空洞闭合比例、病灶吸收比例及痰菌阴转比例差异均具有统计学意义。③两组药物不良反应类型与发生率差异无统计学意义。结论糖尿病合并肺结核患者在有效控制血糖基础上,抗结核治疗中加用胸腺肽注射液能提高细胞免疫水平,加快空洞闭合、痰菌阴转与病灶吸收。
목적：관찰병탐토흉선태재당뇨병합병결핵병환자항결핵치료중적작용。방법장입선적90례당뇨병합병폐결핵환자수궤분위관찰조( n=47례)화대조조( n=43례),대조조재유지혈당기출상여상규항결핵치료,관찰조재차기출상가용흉선태주사액피하주사,련용12주,대비량조치료3개월후항결핵치료효과。결과①치료90 d후,관찰조CD4+구성비급CD4+/CD8+비치명현고우대조조수평저P<0.05,이CD8+구성비(23.3±5.7)%현저저우대조조。②량조혈당공제평은,관찰조여치료조공동폐합비례、병조흡수비례급담균음전비례차이균구유통계학의의。③량조약물불량반응류형여발생솔차이무통계학의의。결론당뇨병합병폐결핵환자재유효공제혈당기출상,항결핵치료중가용흉선태주사액능제고세포면역수평,가쾌공동폐합、담균음전여병조흡수。
Objective To observe the clinical efficacy of thymopeptide in the anti-pulmonary tuberculosis treatment of patients complicated with type 2 diabetes mellitus. Methods 90 pulmonary tuberculosis patients com-plicated with type 2 diabetes mellitus were randomly divided into the observation group ( n=47 cases) and the control group ( n=43 cases) . Based on glucose maintenance the control group was given conventional anti-tuberculosis treat-ment, while the observation group was added with thymopeptide injection subcutaneously. 12 weeks were a treatment course. Results ①90 days after the treatment, the constituent ratio of CD4+ and the ratio of CD4+ /CD8+ were signif-icantly higher in the observation group than in the control group (t=3. 456, P=0. 001;t=4. 708, P=0. 000), and CD8+(23. 3 ± 5. 7 )% was significantly lower than that in the control group ( 28. 6 ± 7. 4 )% ( t =3. 781, P =0. 000).②Blood sugar of the two groups maintained well, but there were significant differences in cavity closure pro-portion ( 50% vs. 22. 7%) , focus absorption ratio ( 55. 3% vs. 32. 6%) and sputum negative conversion rate (46. 8% vs. 25. 6%) between the two groups (fisher P=0. 045;2=4. 712 P=0. 030 2=4. 357 P=0. 037). ③The incidence of adverse reactions had no significant difference between the two groups (χ2 =0. 045, P=0. 833). Conclusion On the effective control of blood glucose basis for pulmonary tuberculosis patients with diabetes melli-tus, anti-tuberculosis treatment applied with thymopeptide injection can enhance cellular immunity level, accelerate cavity closure, sputum negative conversion and focus absorption. anti with enteric.