CAJ | 학술논문

目的：分析老年COPD患者并发肺动脉高压与血清Rho激酶表达的相关性。方法分析我院接受治疗的COPD患者的临床资料。依据患者是否合并肺动脉高压分为观察组、对照组。结果共纳入观察组38例，对照组40例。观察组患者肺动脉平均压、血清ROCK1、单核细胞ROCK1、肿瘤坏死因子α及C-反应蛋白水平均显著高于对照组(P<0.001)。观察组患者血清ROCk1水平与肺动脉高压呈现显著性正相关(P<0.001)。观察组患者单核细胞ROCk1水平与肺动脉高压呈现显著性正相关(P=0.004)。结论合并肺动脉高压的老年COPD患者，外周血及单核细胞内ROCK1表达均升高，且与肺动脉平均压力呈现正相关。提示ROCK1是干预COPD向肺动脉高压进展的新靶点。
목적：분석노년COPD환자병발폐동맥고압여혈청Rho격매표체적상관성。방법분석아원접수치료적COPD환자적림상자료。의거환자시부합병폐동맥고압분위관찰조、대조조。결과공납입관찰조38례，대조조40례。관찰조환자폐동맥평균압、혈청ROCK1、단핵세포ROCK1、종류배사인자α급C-반응단백수평균현저고우대조조(P<0.001)。관찰조환자혈청ROCk1수평여폐동맥고압정현현저성정상관(P<0.001)。관찰조환자단핵세포ROCk1수평여폐동맥고압정현현저성정상관(P=0.004)。결론합병폐동맥고압적노년COPD환자，외주혈급단핵세포내ROCK1표체균승고，차여폐동맥평균압력정현정상관。제시ROCK1시간예COPD향폐동맥고압진전적신파점。
Objective To explore the correlation of ROCK1 in elderly COPD patients complicated with pul-monary arterial hypertension. Methods The clinical data of COPD patients from Jan 2012 to Jun 2013 were collect-ed. 38 COPD patients complicated with pulmonary arterial hypertension were selected as the observation group, and 40 COPD patients without pulmonary arterial hypertension were taken as the control group. Results The mean val-ues of mean pulmonary arterial pressure, ROCK1 in blood and monocytes, TNF-αand CRP in the observation group were significant higher than those in the control group (P<0. 001). In the observation group, there was a positive correlation between the blood ROCK1 and the pulmonary arterial pressure (r=0. 624, P<0. 001) and a positive cor-relation between the monocytes ROCK1 and the pulmonary arterial pressure (r=0. 459, P=0. 004). Conclusion The expression of ROCK1 in blood and monocytes increases in COPD patients with pulmonary arterial hypertension, and there is a positive correlation between ROCK1 and pulmonary arterial pressure. ROCK1 may be a new target to prevent COPD developing into pulmonary arterial hypertension.