CAJ | 학술논문

目的：观察分析白血病患者的肺弥散功能变化。方法对31例肺通气功能正常的白血病患者进行肺弥散功能测定，同时选择30例外科术前患者作为对照组。分别获得两组未用血红蛋白( Hb)校正的弥散量DLCO、DLCO实测值/预计值( A/P)及Hb校正后的DLCO( DLCOAdj)、DLCOAdj( A/P)。结果对照组DLCO与DLCOAdj、DLCO(A/P)与DLCOAdj(A/P)无统计学意义(P>0.05)；白血病组DLCO与DLCOAdj、DLCO(A/P)与DLCOAdj(A/P)有统计学意义(P<0.05)；两组间 DLCO、DLCOAdj、DLCO(A/P)、DLCOAdj (A/P)有统计学意义(P<0.05)。结论白血病患者肺弥散功能有不同程度降低，临床分析肺弥散功能异常的原因时，首先应排除Hb的影响因素，再结合肺CT和临床资料分析其它影响因素。
목적：관찰분석백혈병환자적폐미산공능변화。방법대31례폐통기공능정상적백혈병환자진행폐미산공능측정，동시선택30예외과술전환자작위대조조。분별획득량조미용혈홍단백( Hb)교정적미산량DLCO、DLCO실측치/예계치( A/P)급Hb교정후적DLCO( DLCOAdj)、DLCOAdj( A/P)。결과대조조DLCO여DLCOAdj、DLCO(A/P)여DLCOAdj(A/P)무통계학의의(P>0.05)；백혈병조DLCO여DLCOAdj、DLCO(A/P)여DLCOAdj(A/P)유통계학의의(P<0.05)；량조간 DLCO、DLCOAdj、DLCO(A/P)、DLCOAdj (A/P)유통계학의의(P<0.05)。결론백혈병환자폐미산공능유불동정도강저，림상분석폐미산공능이상적원인시，수선응배제Hb적영향인소，재결합폐CT화림상자료분석기타영향인소。
Objective To observe the changes of lung diffusing capacity of leukemia patients. Methods The changes of lung diffusing capacity of 31 leukemia patients were tested by German CareFusion spirometer, and 30 surgical patients before operation were taken as controls. DLCO&DLCO ( A/P) without Hb adjustment and DLCO-Adj & DLCOAdj ( A/P) with Hb adjustment were recorded. The data were analyzed by CHISS software. Results There was no statistical significance in DLCO vs. DLCOAdj, DLCO ( A/P) vs. DLCOAdj ( A/P) in the control group, but there were significant differences in the study group (P<0. 05) and between the two groups (P<0. 05). Conclusion There are different degree decreases in DLCO of leukemia patients. While clinically analyzing the cau-ses of DLCO disorder, the Hb factor should be excluded first, and other factors are investigated thereafter based on lung CT scan and clinical data.