中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
17期
1094-1097
,共4页
SNCG%CXCR4%胃癌%浸润%转移
SNCG%CXCR4%胃癌%浸潤%轉移
SNCG%CXCR4%위암%침윤%전이
SNCG%CXCR4%gastric cancer%infiltration%metastasis
目的:研究SNCG和CXCR4在胃癌和正常胃黏膜组织中的表达,探讨其在胃癌发生、发展、浸润转移中的作用。方法:应用RT-PCR法检测不同组织中SNCG和CXCR4 mRNA的表达情况。结果:SNCG和CXCR4 mRNA在胃癌组织中的表达量明显高于正常胃黏膜组织(P<0.01);胃癌组织中SNCG mRNA的表达量与癌组织的浸润深度和淋巴结转移有关(P<0.05,P<0.01),CXCR4 mRNA的表达量与淋巴结转移有关(P<0.01);胃癌组织中SNCG mRNA与CXCR4 mRNA的表达量呈正相关(r=0.346,P<0.05)。结论:SNCG和CXCR4在胃癌组织中高表达,可能与胃癌的发生、发展、浸润、转移密切相关。
目的:研究SNCG和CXCR4在胃癌和正常胃黏膜組織中的錶達,探討其在胃癌髮生、髮展、浸潤轉移中的作用。方法:應用RT-PCR法檢測不同組織中SNCG和CXCR4 mRNA的錶達情況。結果:SNCG和CXCR4 mRNA在胃癌組織中的錶達量明顯高于正常胃黏膜組織(P<0.01);胃癌組織中SNCG mRNA的錶達量與癌組織的浸潤深度和淋巴結轉移有關(P<0.05,P<0.01),CXCR4 mRNA的錶達量與淋巴結轉移有關(P<0.01);胃癌組織中SNCG mRNA與CXCR4 mRNA的錶達量呈正相關(r=0.346,P<0.05)。結論:SNCG和CXCR4在胃癌組織中高錶達,可能與胃癌的髮生、髮展、浸潤、轉移密切相關。
목적:연구SNCG화CXCR4재위암화정상위점막조직중적표체,탐토기재위암발생、발전、침윤전이중적작용。방법:응용RT-PCR법검측불동조직중SNCG화CXCR4 mRNA적표체정황。결과:SNCG화CXCR4 mRNA재위암조직중적표체량명현고우정상위점막조직(P<0.01);위암조직중SNCG mRNA적표체량여암조직적침윤심도화림파결전이유관(P<0.05,P<0.01),CXCR4 mRNA적표체량여림파결전이유관(P<0.01);위암조직중SNCG mRNA여CXCR4 mRNA적표체량정정상관(r=0.346,P<0.05)。결론:SNCG화CXCR4재위암조직중고표체,가능여위암적발생、발전、침윤、전이밀절상관。
Objective:To detect expression of SNCG and CXCR4 mRNA in gastric adenocarcinoma and evaluate its function in carcinogenesis, progression, infiltration, and metastasis, as well as the correlation of these proteins. Methods:The expression of SNCG and CXCR4 mRNAs was detected using reverse transcription-polymerase chain reaction in gastric adenocarcinoma and normal gastric mucosa. Results:The expression of SNCG and CXCR4 mRNAs was obviously higher in gastric adenocarcinoma than in normal gastric mucosa (P<0.01). The expression of SNCG mRNA was closely correlated with tumor infiltration depth (P<0.05) and lymph node metas-tasis (P<0.01). The expression of CXCR4 mRNA closely correlated with lymph node metastasis (P<0.01). The expression of SNCG and CXCR4 mRNAs positively correlated in 29 cases of gastric adenocarcinoma (r=0.346, P<0.05). Conclusion:SNCG and CXCR4 may be overexpressed in tumor tissue and may have important functions in tumorigenesis, progression, infiltration, and metastasis of gastric adenocarcinoma.