CAJ | 학술논문

目的：探讨血清胸苷激酶1（ Thymidine Kinase 1，TK1）水平变化在非小细胞肺癌（ Non-Small Cell Lung Cancer，NSCLC）患者临床上的应用价值。方法采用免疫印迹增强化学发光法检测64例NSCLC患者、31例正常健康查体者血清TK1水平，并对44例NSCLC患者手术前后血清TK1水平变化状况进行比较。结果血清TK1水平与NSCLC患者临床分期有关，与NSCLC患者病理类型、年龄和性别无相关，NSCLC患者血清TK1水平明显高于正常对照组（P＜0．01），NSCLC血清TK1水平Ⅳ期明显高于Ⅲ期，Ⅲ期高于Ⅱ期，Ⅱ期高于Ⅰ期、两两比较差异有统计学意义（P＜0．01～0．05），手术后NSCLC患者血清TK1水平明显低于手术前（P＜0．01）。结论血清TK1表达水平与NSCLC及其临床病理特征密切相关，血清TK1检测对NSCLC患者病情判断、疗效和预后评价有一定的临床意义。
목적：탐토혈청흉감격매1（ Thymidine Kinase 1，TK1）수평변화재비소세포폐암（ Non-Small Cell Lung Cancer，NSCLC）환자림상상적응용개치。방법채용면역인적증강화학발광법검측64례NSCLC환자、31례정상건강사체자혈청TK1수평，병대44례NSCLC환자수술전후혈청TK1수평변화상황진행비교。결과혈청TK1수평여NSCLC환자림상분기유관，여NSCLC환자병리류형、년령화성별무상관，NSCLC환자혈청TK1수평명현고우정상대조조（P＜0．01），NSCLC혈청TK1수평Ⅳ기명현고우Ⅲ기，Ⅲ기고우Ⅱ기，Ⅱ기고우Ⅰ기、량량비교차이유통계학의의（P＜0．01～0．05），수술후NSCLC환자혈청TK1수평명현저우수술전（P＜0．01）。결론혈청TK1표체수평여NSCLC급기림상병리특정밀절상관，혈청TK1검측대NSCLC환자병정판단、료효화예후평개유일정적림상의의。
Objective To investigate the changes and its clinical value of serum Thymidine Kinase 1 (TK1) in patients with non-small cell lung cancer(NSCLC).Methods Sensitive chemiluminescence dot-blot assay were available to detect the level of serum TK 1 in 64 cases of patients with NSCLC and 31 cases of normal control subject, compared with 44 patients with NSCLC pre-and post-operation.Results Serum TK1 was correlated with clinical stage , and not with pathologic types , age and sex of patients with NSCLC , the level of serum TK1 were elevated in all subgroups of patients with NSCLC compared to the controls (P<0.01), the serum TK1 level in stage Ⅳwas higher than that in stage Ⅲ, in stage Ⅲ it was higher than that in stage Ⅱ, and in stage Ⅱit was higher than that in stageⅠ(P<0.01~0.05), the serum TK1 levels were remarkably reduced in patients with NSCLC after operation(P<0.01).Conclusions This study demonstrates that the expression of serum TK1 have a relationship with clinical pathological feature of patients with NSCLC , it may be act as one index to assess the disease status and the prognosis of NSCLC .