CAJ | 학술논문

目的探讨18 F-脱氧葡萄糖正电子发射断层显像/计算机体层扫描（18 F-FDG PET/CT）在不明原因发热（ FUO）患者中筛查淋巴瘤的价值。方法回顾性分析41例不明原因发热患者的临床病历资料及18 F-FDG PET/CT 影像结果。结果41例FUO患者中有13例PET/CT显像示淋巴瘤可能，经病理检查12例确诊为淋巴瘤。PET/CT结果对FUO病因淋巴瘤诊断的灵敏度、特异度、准确度、阳性预测值、阴性预测值分别为：100%（12/12）、96.2%（25/26）、97.4%（37/38）、92.3%（12/13）、100%（25/25）；淋巴瘤组和非淋巴瘤组浅表淋巴结和深部淋巴结放射性增高例数比均无统计学差异，而两组的最大标准化摄取值（ SUVmax）比较都具有显著性差异；两组瘤患者脾脏增大比率、放射性增高例数比率和SUVmax值比较均有显著性差异；两组全身多中心骨髓放射性增高例数比率的比较无显著性差异，SUVmax值的比较差异具有统计学意义。结论18 F-FDG PET/CT可通过淋巴结、脾脏及全身多中心骨髓的SUVmax值为在FUO中筛查淋巴瘤患者提供重要参考价值。
목적탐토18 F-탈양포도당정전자발사단층현상/계산궤체층소묘（18 F-FDG PET/CT）재불명원인발열（ FUO）환자중사사림파류적개치。방법회고성분석41례불명원인발열환자적림상병력자료급18 F-FDG PET/CT 영상결과。결과41례FUO환자중유13례PET/CT현상시림파류가능，경병리검사12례학진위림파류。PET/CT결과대FUO병인림파류진단적령민도、특이도、준학도、양성예측치、음성예측치분별위：100%（12/12）、96.2%（25/26）、97.4%（37/38）、92.3%（12/13）、100%（25/25）；림파류조화비림파류조천표림파결화심부림파결방사성증고례수비균무통계학차이，이량조적최대표준화섭취치（ SUVmax）비교도구유현저성차이；량조류환자비장증대비솔、방사성증고례수비솔화SUVmax치비교균유현저성차이；량조전신다중심골수방사성증고례수비솔적비교무현저성차이，SUVmax치적비교차이구유통계학의의。결론18 F-FDG PET/CT가통과림파결、비장급전신다중심골수적SUVmax치위재FUO중사사림파류환자제공중요삼고개치。
Objective Toexplorethevalueof18F-FDGPET/CTinscreeninglymphomaoftheFUOpatients.Methods Theclinical data and imaging results of 41 FUO patients were analyzed retrospectively,to explore the value of PET/CT in screening lymphoma of the FUO pa-tients.Results Amongthe41FUOpatients,13caseswererevealedlymphomabyPET/CTimaging,ofwhich12caseswerediagnosedaslym-phoma by pathological examination. The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of lymphoma di-agnosis of FUO patients with PET/CT were:100%(12/12),96. 2%(25/26),97. 4%(37/38),92. 3%(12/13),100%(25/25),respec-tively. No statistical difference in increased radioactivity ratio of superficial and deep lymph nodes were found between lymphoma and non-lym-phoma group,but there is significant difference in SUVmax value between the two groups patients. There is significant difference in the ratio of in-creased size of spleen and increased radioactivity and SUVmax value between the two groups. There is no significant difference in the ratio of in-creased whole body multi-center bone marrow radioactivity between the two groups. And there is significant difference in SUVmax value between thetwogroups.Conclusion 18F-FDGPET/CTimagingcanprovideimportantreferenceinformationinscreeninglymphomaofFUOpatientsby SUVmax value of lymph nodes、spleen and whole body multi-center bone marrow.