CAJ | 학술논문

目的：探讨利奈唑胺对老年患者血液系统产生的不良影响，为合理用药和提高老年患者用药安全性提供参考。方法回顾性分析2011~2012年在住院期间曾使用利奈唑胺抗感染治疗的老年患者血液系统异常的发生率及特点。结果使用利奈唑胺后15.6%患者白细胞降低至正常值以下，但停药后多数可恢复。42.2%患者发生血红蛋白下降，其中不到半数患者停药后可恢复至治疗前水平，且需时间较长。78.1%患者出现血小板降低，其中42.2%降低至正常值以下，25%降至50×109/ L 以下，大多数患者停药2周后血小板可恢复至治疗前水平。结论老年患者使用利奈唑胺后血液系统不良反应的发生率和严重程度高于其他人群，故老年患者使用利奈唑胺过程中需密切监测血常规。
목적：탐토리내서알대노년환자혈액계통산생적불량영향，위합리용약화제고노년환자용약안전성제공삼고。방법회고성분석2011~2012년재주원기간증사용리내서알항감염치료적노년환자혈액계통이상적발생솔급특점。결과사용리내서알후15.6%환자백세포강저지정상치이하，단정약후다수가회복。42.2%환자발생혈홍단백하강，기중불도반수환자정약후가회복지치료전수평，차수시간교장。78.1%환자출현혈소판강저，기중42.2%강저지정상치이하，25%강지50×109/ L 이하，대다수환자정약2주후혈소판가회복지치료전수평。결론노년환자사용리내서알후혈액계통불량반응적발생솔화엄중정도고우기타인군，고노년환자사용리내서알과정중수밀절감측혈상규。
Objective To investigate the adverse effects on hematological system among elderly patient caused by linezolid. Methods The clinical data of 64 elderly patients who were treated with linezolid between 2011 ~ 2012 when hospitalized in our department were analyzed ret-rospectively. Results Leukocytopenia occurred in 15. 6 percent of patients,but normalized soon after drug withdrawal in most of them. Decrease of hemoglobin occurred in 42. 2 percent of patients,and less than half of them could return to the baseline. The incidence of thrombocytopenia was 42. 2% ,and the platelet count of 16(25% )patients decreased below 50 × 109 / L. But the platelet count of most patients would return to the baseline at two weeks after drug withdrawal. Conclusion The incidence and the severity of adverse reactions to hematological system caused by linezolid in elderly patient were higher than that in general population. Complete blood count should be monitored carefully in elderly patients who are treated with linezolid.