CAJ | 학술논문

目的：观察夜交藤提取物对小鼠中枢神经系统的作用。方法清洁级小鼠80只，随机分为4组。其中每组各设夜交藤组（灌服夜交藤提取物）和对照组（灌服等体积生理盐水），每组10只。4组分别观察夜交藤提取物对小鼠自主活动的影响、对延长异戊巴比妥钠诱导的小鼠睡眠时间、对异戊巴比妥钠致小鼠睡眠率的影响以及对士的宁中枢兴奋作用的影响。结果夜交藤提取物对小鼠自主活动呈明显抑制作用，可延长异戊巴比妥钠诱导的小鼠睡眠时间，对阈下催眠剂量的异戊巴比妥钠有协同作用，能显著降低士的宁引起的惊厥率。结论夜交藤提取物对小鼠有明显的镇静、催眠作用。
목적：관찰야교등제취물대소서중추신경계통적작용。방법청길급소서80지，수궤분위4조。기중매조각설야교등조（관복야교등제취물）화대조조（관복등체적생리염수），매조10지。4조분별관찰야교등제취물대소서자주활동적영향、대연장이무파비타납유도적소서수면시간、대이무파비타납치소서수면솔적영향이급대사적저중추흥강작용적영향。결과야교등제취물대소서자주활동정명현억제작용，가연장이무파비타납유도적소서수면시간，대역하최면제량적이무파비타납유협동작용，능현저강저사적저인기적량궐솔。결론야교등제취물대소서유명현적진정、최면작용。
Objective To study the pharmacological effects of the Caulis Polygoni Multiflori extraction on central nervous system. Meth-ods The pharmacological effects of the Caulis Polygoni Multiflori extracting was observed on the autonomic activities of mice,the time of sleep in-duced by Sodium Amo Barbital,the sleeping synergistic action of mice with Sodium Amo Barbital at sub - threshold and the central inhibitory effects in mice induced by Strychnine. Results The Caulis Polygoni Multiflori extraction could inhibit autonomic activities of the mice,prolong the sleep time induced by Sodium Amo Barbital,enhance the rate of falling asleep induced by Sodium Amo Barbital and inhibit the central stimulating effects induced by Strychnine. Conclusion The Caulis Polygoni Multiflori extraction has significant sedative and hypnosis effects.