CAJ | 학술논문

目的通过检测并分析婴幼儿轮状病毒性肠炎与非轮状病毒感染性肠炎患儿心肌酶的水平，探讨轮状病毒感染与心肌损伤的相关性。方法54例婴幼儿轮状病毒性肠炎的患儿作为观察组，78例轮状病毒阴性的腹泻病患儿作为对照组。两组患儿入院后抽取取空腹血清检查心肌酶[磷酸肌酸激酶（CK）及其同工酶（CK - MB）、门冬氨酸氨基转移酶（AST）]进行比较分析。两组患儿经治疗，腹泻症状消失后，将心肌酶三项均增高患儿的血清心肌酶进行治疗前后的分析比较。结果观察组中血清心肌酶三项（AST、CK - MB、CK）的水平较对照组高，差异有显著性（ P ﹤0.05）。且入院时，观察组心肌酶三项均异常者有30例，占55.6%；对照组心肌酶三项均异常者有13例，占16.7%。观察组心肌酶异常者比率显著高于对照组，差异有显著性（ P ﹤0.05）。治疗前，观察组心肌酶三项均异常者心肌酶水平较对照组增高，差异有显著性（ P ﹤0.05）；治疗后，两组心肌酶三项均异常者心肌酶水平差异无统计学意义（ P ﹥0.05）。结论婴幼儿轮状病毒性肠炎较非轮状病毒性腹泻更容易导致患儿心肌的损伤，经治疗后，心肌酶可以在短时间内恢复正常。因此，在治疗婴幼儿轮状病毒性肠炎时应进行心肌酶的检测，并注意排除病毒性心肌炎。
목적통과검측병분석영유인륜상병독성장염여비륜상병독감염성장염환인심기매적수평，탐토륜상병독감염여심기손상적상관성。방법54례영유인륜상병독성장염적환인작위관찰조，78례륜상병독음성적복사병환인작위대조조。량조환인입원후추취취공복혈청검사심기매[린산기산격매（CK）급기동공매（CK - MB）、문동안산안기전이매（AST）]진행비교분석。량조환인경치료，복사증상소실후，장심기매삼항균증고환인적혈청심기매진행치료전후적분석비교。결과관찰조중혈청심기매삼항（AST、CK - MB、CK）적수평교대조조고，차이유현저성（ P ﹤0.05）。차입원시，관찰조심기매삼항균이상자유30례，점55.6%；대조조심기매삼항균이상자유13례，점16.7%。관찰조심기매이상자비솔현저고우대조조，차이유현저성（ P ﹤0.05）。치료전，관찰조심기매삼항균이상자심기매수평교대조조증고，차이유현저성（ P ﹤0.05）；치료후，량조심기매삼항균이상자심기매수평차이무통계학의의（ P ﹥0.05）。결론영유인륜상병독성장염교비륜상병독성복사경용역도치환인심기적손상，경치료후，심기매가이재단시간내회복정상。인차，재치료영유인륜상병독성장염시응진행심기매적검측，병주의배제병독성심기염。
Objective To explore the significance of serum level of myocardial enzymes in infantile patients with rotavirus enteritis. Methods A total of 132 infantile patients with diarrhea,ranging from 6 months to 3 years old admitted in 2012 were allocated in this study,54 of them with positive rotavirus antigen were listed as observation group,and 78 cases with negative rotavirous antigen as control group. Serum myo-cardial enzymes as creatine phosphate kinase(CK),creatine phosphate kinase isoenzyme(CK - MB)and aspartic transaminase(AST)were ana-lyzed and compared between these two groups before and after treatment. Results Serum levels of 3 enzymes(AST,CK - MB and CK)in obser-vation group were higher than those of control group,and the difference was statistically significant( P ﹤ 0. 05). There were 30 cases in observa-tion group with 3 kinds of abnormal cardiac enzymes accounted for 55. 6% ;and 13 cases(16. 7% )with 3 kinds of abnormal cardiac enzymes in control group. The percentage of abnormal enzymes in observation group was significantly higher than that of control group,and the difference was significant( P ﹤ 0. 05). Before treatment,the percentage of 3 abnormal cardiac enzymes in observation group was higher than that of control group,and the difference was statistically significant( P ﹤ 0. 05). After treatment,the difference in levels of three abnormal cardiac enzymes in both groups was not significant( P ﹥ 0. 05). Conclusion Infants with rotavirus diarrhea were susceptible to myocardial impairment. The enzy-matic value will be recovered to normal within a short interval after treatment. Myocardial enzymes including CK,CK - MB and AST should be rou-tinely monitored in infants with rotavirus infection.