CAJ | 학술논문

目的：探讨乳腺癌患者血清中甲状腺激素水平的变化，研究甲状腺激素受体 THRβ1在乳腺癌组织中的表达及其与临床病理因素之间的相互关系。方法①51例乳腺癌患者为观察组，对照组为51例健康女性，统计其血清中甲状腺激素（T3、T4、TSH）水平，并结合患者临床病理指标进行分析。②选51例乳腺癌组织和51例正常组织，应用RT - PCR 琼脂糖凝胶电泳检测标本中 THRβ1mRNA 表达情况，分析与临床病理的关系。结果①乳腺癌患者血清中甲状腺激素 T3水平下降。肿瘤直径越大、有淋巴结转移、临床分期越晚，其 T3降低越显著。②在51例乳腺癌组织中， THRβ1 mRNA 19例表达阳性，阳性率为37.2%；而在51例癌旁正常乳腺组织中45例表达阳性，阳性率为88.2%。在腺癌组中表达率明显低于正常乳腺组（ P ﹤0.05）。THRβ1 mRNA 低表达与年龄、病理类型无关（ P ﹥0.05），而与淋巴结转移、肿瘤大小、TNM 分期显著相关（ P ﹤0.05）。结论乳腺癌患者血清甲状腺激素 T3水平下降，T4、TSH 无明显变化。且肿瘤直径越大、有淋巴结转移、临床分期越晚，其 T3降低越显著；THRβ1mRNA 的低表达在乳腺癌的发生中起一定作用。提示乳腺癌与甲状腺激素之间存在着相关性。
목적：탐토유선암환자혈청중갑상선격소수평적변화，연구갑상선격소수체 THRβ1재유선암조직중적표체급기여림상병리인소지간적상호관계。방법①51례유선암환자위관찰조，대조조위51례건강녀성，통계기혈청중갑상선격소（T3、T4、TSH）수평，병결합환자림상병리지표진행분석。②선51례유선암조직화51례정상조직，응용RT - PCR 경지당응효전영검측표본중 THRβ1mRNA 표체정황，분석여림상병리적관계。결과①유선암환자혈청중갑상선격소 T3수평하강。종류직경월대、유림파결전이、림상분기월만，기 T3강저월현저。②재51례유선암조직중， THRβ1 mRNA 19례표체양성，양성솔위37.2%；이재51례암방정상유선조직중45례표체양성，양성솔위88.2%。재선암조중표체솔명현저우정상유선조（ P ﹤0.05）。THRβ1 mRNA 저표체여년령、병리류형무관（ P ﹥0.05），이여림파결전이、종류대소、TNM 분기현저상관（ P ﹤0.05）。결론유선암환자혈청갑상선격소 T3수평하강，T4、TSH 무명현변화。차종류직경월대、유림파결전이、림상분기월만，기 T3강저월현저；THRβ1mRNA 적저표체재유선암적발생중기일정작용。제시유선암여갑상선격소지간존재착상관성。
Objective To explore patients with breast cancer of serum thyroid hormone level changes,and to investigate thyroid hormone receptorβ1(THRβ1)in breast cancer tissues and its relationship with clinicopathological factors relate to one another. Methods ①51 breast cancer patients were selected for the observation and were considered as breast cancer group. 51 normal patients were considered as the control group. Their serum thyroid hormone(T3 ,T4 ,TSH)was examined and then carry out comparative analysis. ②RT - PCR was used to detect the expression of THRβ1mRNA in 51 human breast cancer and 51 normal breast tissues. Results ①The content of T3 in serum of the breast cancer patients is decreased compared with that of normal group. ②A positive rate of THRβ1mRNA was 37. 2% in human breast cancer and 87. 2% in normal breast tissues. The expression level was lower in breast cancer than that of normal breast tissues( P ﹤ 0. 05). The expression was not cor-related with patients' age,histologic types. The expression level was lower in late - stage tumors(stage III)than that of early - stage tumors(stage I and II),in tumors with lymph node metastasis than those without lymph node metastasis,and in large - sized tumors than that of small - sized ones. Conclusion The content of T3 serum of the breast cancer patients is decreased. THRβ1 might play all important role in the development of invasion and metastasis of breast cancer.