临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2014年
18期
1511-1513
,共3页
程雪菊%马凯来%徐凤娟%王金湖
程雪菊%馬凱來%徐鳳娟%王金湖
정설국%마개래%서봉연%왕금호
卵巢癌%人附睾蛋白 4%CA125%CA199
卵巢癌%人附睪蛋白 4%CA125%CA199
란소암%인부고단백 4%CA125%CA199
Ovarian cancer%Human epididymis protein 4%CA125%CA199
目的：探讨 HE4等血清标志物检测在卵巢肿瘤早期诊断及随访中的应用价值。方法选择卵巢恶性疾病肿瘤患者35例（研究组）和卵巢良性疾病患者152例（对照组）。检测血清人附睾蛋白4（HE4）、糖类抗原125（CA125）、糖类抗原199（CA199）、癌胚抗原（CEA）、甲胎蛋白（AFP）水平，并对卵巢癌患者随访时检测 HE4和 CA125水平。结果研究组 HE4、CA125和 CA199显著高于对照组，CEA、AFP 在两组中无显著差异。HE4+ CA125+ CA199检测获得了最高诊断效能，其灵敏度、特异度、阳性预测值、阴性预测值、符合率分别为91.4%、81.6%、53.3%、97.6%、83.4%，ROC 曲线下面积为0.86。HE4浓度变化预测卵巢癌阴转、阳转的符合率分别为75.9%和83.3%。HE4+ CAl25联合检测预测卵巢癌阴转、阳转的符合率分别为79.3%和100%。结论 HE4+ CA125+ CA199对早期卵巢癌有较高的诊断效能；HE4+ CA125可作为卵巢癌较好的病情和疗效动态监测指标。
目的：探討 HE4等血清標誌物檢測在卵巢腫瘤早期診斷及隨訪中的應用價值。方法選擇卵巢噁性疾病腫瘤患者35例（研究組）和卵巢良性疾病患者152例（對照組）。檢測血清人附睪蛋白4（HE4）、糖類抗原125（CA125）、糖類抗原199（CA199）、癌胚抗原（CEA）、甲胎蛋白（AFP）水平，併對卵巢癌患者隨訪時檢測 HE4和 CA125水平。結果研究組 HE4、CA125和 CA199顯著高于對照組，CEA、AFP 在兩組中無顯著差異。HE4+ CA125+ CA199檢測穫得瞭最高診斷效能，其靈敏度、特異度、暘性預測值、陰性預測值、符閤率分彆為91.4%、81.6%、53.3%、97.6%、83.4%，ROC 麯線下麵積為0.86。HE4濃度變化預測卵巢癌陰轉、暘轉的符閤率分彆為75.9%和83.3%。HE4+ CAl25聯閤檢測預測卵巢癌陰轉、暘轉的符閤率分彆為79.3%和100%。結論 HE4+ CA125+ CA199對早期卵巢癌有較高的診斷效能；HE4+ CA125可作為卵巢癌較好的病情和療效動態鑑測指標。
목적：탐토 HE4등혈청표지물검측재란소종류조기진단급수방중적응용개치。방법선택란소악성질병종류환자35례（연구조）화란소량성질병환자152례（대조조）。검측혈청인부고단백4（HE4）、당류항원125（CA125）、당류항원199（CA199）、암배항원（CEA）、갑태단백（AFP）수평，병대란소암환자수방시검측 HE4화 CA125수평。결과연구조 HE4、CA125화 CA199현저고우대조조，CEA、AFP 재량조중무현저차이。HE4+ CA125+ CA199검측획득료최고진단효능，기령민도、특이도、양성예측치、음성예측치、부합솔분별위91.4%、81.6%、53.3%、97.6%、83.4%，ROC 곡선하면적위0.86。HE4농도변화예측란소암음전、양전적부합솔분별위75.9%화83.3%。HE4+ CAl25연합검측예측란소암음전、양전적부합솔분별위79.3%화100%。결론 HE4+ CA125+ CA199대조기란소암유교고적진단효능；HE4+ CA125가작위란소암교호적병정화료효동태감측지표。
Objective To investigate human epididymis protein 4(HE4)and other serum markers in the early diagnosis and follow - up of ovarian cancer. Methods Thirty - five patients with ovarian cancer( study group)and 152 patients with benign ovarian diseases( control group)were collected. Serum HE4,CA125,CA199,CEA,alpha - fetoprotein(AFP)levels were detected. The levels of HE4 and CA125 were also detected in ovarian cancer patients at follow - up. Results HE4,CA125 and CA199 levels were significantly higher in study group. There were no significant differences in the levels of CEA and AFP between two groups. The combined detection of HE4,CA125 and CA199 reached highest diagnostic performance,with sensitivity,specificity,positive predictive value,negative predictive value,and consistent rate of 91. 4% , 81. 6% ,53. 3% ,97. 6% ,and 83. 4% ,respectively. The area under the ROC curve was 0. 86. Consistent rates in HE4 concentration to predict positive change and negative change in ovarian cancer were 75. 9% and 83. 3% ,respectively. Consistent rates in combined detection of HE4 and CA125 to predict positive change and negative change in ovarian cancer were 79. 3% and 100% ,respectively. Conclusion The combined detec-tion of HE4,CA125,and CA199 has a high performance in early diagnosis of ovarian cancer;and the combined detection of HE4 and CA125 can be a good indicator for dynamic monitoring of disease status and therapeutic effect in ovarian cancer patients.
