临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2014年
18期
1522-1525
,共4页
急性胆源性胰腺炎%超敏C反应蛋白%降钙素原
急性膽源性胰腺炎%超敏C反應蛋白%降鈣素原
급성담원성이선염%초민C반응단백%강개소원
Acutebilirypancreatitis%High-sensitivityC-reactiveprotein%Procalcitonin
目的探讨血清超敏C反应蛋白( hs-CRP)及降钙素原( PCT)与急性胆源性胰腺炎( ABP)病情严重程度及预后的关系。方法选取ABP患者42例,根据其病情严重程度分为水肿型组(24例),出血坏死型组(18例);根据其预后分为生存组(38例)和死亡组(4例)。选取单纯胆囊结石患者46例作为对照组。分别于入院第1、3、7天抽取静脉血检测血清hs-CRP和PCT水平,同时进行急性生理和慢性健康评分标准II( APACHE II)评分。结果与对照组比较入院第1天水肿型组和出血坏死型组血清hs-CRP和PCT水平均升高( P ﹤0.01),出血坏死型组升高更明显( P ﹤0.01);入院第3天时水肿型组和出血坏死型组血清hs-CRP和PCT水平均明显升高达到峰值,经过常规治疗后,入院第7天两组的hs-CRP和PCT水平均有下降,hs-CRP和PCT水平与APCHE Ⅱ评分呈正相关( P ﹤0.05)。ABP患者生存组血清hs-CRP和PCT水平明显低于死亡组( P ﹤0.05)。结论血清hs-CRP和PCT水平与ABP的发生发展相关,可通过观察血清hs-CRP和PCT水平变化评估ABP的严重程度和预后。
目的探討血清超敏C反應蛋白( hs-CRP)及降鈣素原( PCT)與急性膽源性胰腺炎( ABP)病情嚴重程度及預後的關繫。方法選取ABP患者42例,根據其病情嚴重程度分為水腫型組(24例),齣血壞死型組(18例);根據其預後分為生存組(38例)和死亡組(4例)。選取單純膽囊結石患者46例作為對照組。分彆于入院第1、3、7天抽取靜脈血檢測血清hs-CRP和PCT水平,同時進行急性生理和慢性健康評分標準II( APACHE II)評分。結果與對照組比較入院第1天水腫型組和齣血壞死型組血清hs-CRP和PCT水平均升高( P ﹤0.01),齣血壞死型組升高更明顯( P ﹤0.01);入院第3天時水腫型組和齣血壞死型組血清hs-CRP和PCT水平均明顯升高達到峰值,經過常規治療後,入院第7天兩組的hs-CRP和PCT水平均有下降,hs-CRP和PCT水平與APCHE Ⅱ評分呈正相關( P ﹤0.05)。ABP患者生存組血清hs-CRP和PCT水平明顯低于死亡組( P ﹤0.05)。結論血清hs-CRP和PCT水平與ABP的髮生髮展相關,可通過觀察血清hs-CRP和PCT水平變化評估ABP的嚴重程度和預後。
목적탐토혈청초민C반응단백( hs-CRP)급강개소원( PCT)여급성담원성이선염( ABP)병정엄중정도급예후적관계。방법선취ABP환자42례,근거기병정엄중정도분위수종형조(24례),출혈배사형조(18례);근거기예후분위생존조(38례)화사망조(4례)。선취단순담낭결석환자46례작위대조조。분별우입원제1、3、7천추취정맥혈검측혈청hs-CRP화PCT수평,동시진행급성생리화만성건강평분표준II( APACHE II)평분。결과여대조조비교입원제1천수종형조화출혈배사형조혈청hs-CRP화PCT수평균승고( P ﹤0.01),출혈배사형조승고경명현( P ﹤0.01);입원제3천시수종형조화출혈배사형조혈청hs-CRP화PCT수평균명현승고체도봉치,경과상규치료후,입원제7천량조적hs-CRP화PCT수평균유하강,hs-CRP화PCT수평여APCHE Ⅱ평분정정상관( P ﹤0.05)。ABP환자생존조혈청hs-CRP화PCT수평명현저우사망조( P ﹤0.05)。결론혈청hs-CRP화PCT수평여ABP적발생발전상관,가통과관찰혈청hs-CRP화PCT수평변화평고ABP적엄중정도화예후。
Objective Toexploretherelationshipbetweenthelevelsofserumhigh-sensitivityC-reactiveprotein(hs-CRP)andpro-calcitonin(PCT)andtheseverityandprognosisofacutebiliarypancreatitis(ABP).Methods Forty-twoABPpatientsweredividedintoedema group(n=24)and hemorrhagic necrosis group(n=18)according to the severity;and survival group(n=38)and death group(n=4)accord-ing to the prognosis. Forty-six patients with gallbladder stones were selected as the control. Serum hs-CRP and PCT levels and Acute Physiology andChronicHealthEvaluationII(APACHEII)scoreweredeterminedonday1,3and7afteradmission.Results Comparedwithcontrolgroup serum hs-CRP and PCT were elevated( P ﹤0. 01)in both edema and hemorrhagic necrosis group,and more significantly in hemorrhagic necro-sis group( P ﹤0. 01)on day 1 after admission. Serum hs-CRP and PCT levels in both groups reached peak level on day 3,they were decreased on day 7 after conventional treatment. In addition,APCHE II score was positively correlated with hs-CRP and PCT levels( P ﹤0. 05). Conclu-sion Serumhs-CRPandPCTlevelsareassociatedwiththedevelopmentofABPandcanbeusedtoassesstheseverityandprognosisofABP.